عودة

 

الأستاذ الدكتور/ طارق أبوالفضل محمد حسن
أستاذ بقسم الكيمياء الطبية، كلية الصيدلة، جامعة اسيوط
تفاصيل السيرة الذاتية

بيانات ال MIS

دخول الإعضاء

تواصل مع العضو نسخة للطباعة
العنوان الحالى فسم الكيمياء الطبية- كلية الصيدلة / جامعة أسيوط - أسيوط 71526 - مصر
تليفون المكتب 002088411321
الفاكس +20882080774
البريد الالكترونى fadl@aun.edu.eg
Fadl@aun.edu.eg
google scholar link http://scholar.google.com.eg/citations?user=e2ALmfAAAAAJ&hl=en

  • دكتوراه فى العلوم الصيدلية ( الكيمياء الصيدلية الطبية ) ، كلية الصيدلة ، جامعةجوساى اليابانية وجامعة أسيوط (برنامج الإشراف المشترك)، 1994
  • ماجستير فى العلوم الصيدلية ( الكيمياء الصيدلية ) ، كلية الصيدلة ، جامعة أسيوط، 1989
  • بكالوريوس فى العلوم الصيدلية، كلية الصيدلة ، جامعة أسيوط ، 1984
الدرجات العلمية :
  • أستاذ بقسم الكيمياء الطبية، كلية الصيدلة، جامعة اسيوط، 2004
  • أستاذ مساعد بقسم الكيمياء الطبية، كلية الصيدلة، جامعة اسيوط، 1999
  • مدرس بقسم الكيمياء الطبية، كلية الصيدلة، جامعة اسيوط، 1994
  • مدرس مساعد بقسم الكيمياء الطبية، كلية الصيدلة، جامعة اسيوط، 1989
  • معيد بقسم الكيمياء الطبية، كلية الصيدلة، جامعة أسيوط، 1984
المناصب الادارية :
المناصب السابقة :
وكيل الكلية لشئون التعليم والطلاب، كلية الصيدلة، جامعة أسيوط, في الفترة من (10-2013 إلى 10-2016 )

المجالات البحثية:
Amantadine Amides Prodrugs , Hepatic Delivery Systems , Anticancer Agents , Spectrometric Monitoring , Microwave-Assisted Solution-Phase Synthesis , Potential Anti-tubercular Activity , Solution-Phase Synthesis

الابحاث :

1-Tilal Elsaman, Omar A. Al-Deeb, Tarek Aboul-Fadl., Synthesis, Characterization and Antiproliferative Activity of Certain Meclofenamic Acid Amides, Asian Journal of Chemistry, Asian Publication Corporation, 29(2), 291-295 , http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=29_2_12, 2017
2-Hajjaj H. M. Abdu-Allah, Bahaa G. M. Youssif, Mostafa H. Abdelrahman, Mohammed K. Abdel-Hamid, Rudraraju S. Reshma, Perumal Yogeeswari, Tarek Aboul-Fadl, Dharmarajan Sriram, Synthesis and Anti-Mycobacterial Activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: Revitalizing an Old Drug, Archives of Pharmacal Research , Springer , Vol, 40, No. 2, pp. 168-179, http://link.springer.com/article/10.1007/s12272-016-0882-x?wt_mc=Internal.Event.1.SEM.ArticleAuthorAssignedToIssue>, 2017
البحث كاملا
3-Tilal Elsaman, Omar A.A. Aldeeb, Tarek Aboul-Fadl, Elnazeer I. Hamedelneil, Synthesis, characterization and pharmacological evaluation of certain enzymatically cleavable NSAIDs amide prodrugs, Bioorganic Chemistry , elsevier, 70(2), 144-152, http://dx.doi.org/10.1016/j.bioorg.2016.12.005, 2017
البحث كاملا
4-Tilal Elsaman, Omar A. A. Aldeeb, Tarek Aboul-Fadl and Abdullah Al-Dhfyan , Synthesis and antiproliferative activity of some novel amides of flufenamic acid and diclofenac, Der Pharma Chemica , 8(2), 434-443 , http://derpharmachemica.com/vol8-iss2/DPC-2016-8-2-434-443.pdf, 2016
5-Hajjaj H. M. Abdu-Allah, Bahaa G. M. Youssif, Mustafa H. Abd-Elrhman, Mohammed K. Abdel-Hamid, Tarek Aboul-Fadl, and D. Sriram. , Synthesis Of New 4-Aminosalicylates-, Triazole- and Hydrazide-Based Conjugates With Potential Anti-Tubercular Activity. , 52nd International Conference on Medicinal Chemistry (RICT 2016), Caen-France, July 6 -8, 2016., 2016
6-Ahmed M. Galal Osman, Ehab A. Abourashed, Desmond Slade, Safwat A. Ahmed, Waseem Gul, Shabana I. Khan, Tarek Abo Elfadl, Olivia R. Dale, Afeef S. Husni, Stephen J. Cutler, Mahmoud A. ElSohly. , Synthesis and In Vitro Evaluation of Ferutinol Aryl Esters for Estrogenic Activity and Affinity Toward Cannabinoid Receptors, Medicinal Chemistry Research , Springer, Vol. 24, pp. 2670-2678 , DOI 10.1007/s00044-015-1319-7, 2015
البحث كاملا
7-Tarek Aboul-Fadl, Mohammed K. Abdel-Hamid and Adel F. Youssef, Schiff Bases of Indoline-2,3-dione (Isatin) Derivatives as Efficient Agents Against Resistant Strains of Mycobacterium tuberculosis, Der Pharma Chemica , 7(8), 217-225 , 2015
8-Tarek Aboul-Fadl, Tilal Elsaman, Omar A. Al-Deeb, Hazem A. Ghabbour, C. S. Chidan Kumar, Fun Hoong Kun, Some New NSAIDs Prodrugs: An Efficient Synthesis, Spectral Characterization and X-ray Crystal Structure Studies, Asian J. Chem. , Vol.26, No.16, PP.5249-5254, http://dx.doi.org/10.14233/ajchem.2014.16949, 2014
9-Tarek Aboul-Fadl, Suliman S. Al-Hamad, Kevin Lee, Nan Li, Bernard D. Gary, Adam B. Keeton, Gary A. Piazza, Mohammed K. Abdel-Hamid, Novel Non-Cyclooxygenase Inhibitory Derivatives of Naproxen for Colorectal Cancer Chemoprevention, Med. Chem. Res, DOI 10.1007/s00044-014-0979-z, Springer, Vol.23, PP.4177-4188 , http://link.springer.com/journal/44, 2014
10-A.A. Radwan, T. Aboul-Fadl, A. Al-Dhfyan, W.M. Abdel-Mageed, Synthesis and Characterization of bis-3,5-Disubstituted Thiadiazine-2-thione Derivatives as Anticancer Agents, Asian J. Chem., Vol. 26, No. 23, pp. 8145-8150, http://dx.doi.org/10.14233/ajchem.2014.17636, 2014
11-Samy Emara, Tarek Aboul-Fadl, Abdel Nasser El-Shorbagy, Maha Kamal, Walaa Zarad, Mohamed Abdel Kawi, A Combined Experimental Green Flow-Injection Procedure and Computational Analysis to Determine Amino Acids, American Chemical Science Journal, SCIENCEDOMAIN international, 3 - 4, 419-433, http://www.sciencedomain.org/issue.php?iid=242&id=16, 2013
12-Hatem A. Abdel-Aziz, Tarek Aboul-Fadl, Abdul-Rahman M. Al-Obaid, Mohamed Ghazzali, Abdullah Al-Dhfyan, Alessandro Contini, Design, Synthesis and Pharmacophoric Model Building of Novel Substituted Nicotinic Acid Hydrazones with Potential Antiproliferative Activity, Arch Pharm. Res., DOI: 10.1007/s12272-012-0904-2, Vol. 35, No. 9, pp. 1543-1552, 2012
13-Tarek Aboul-Fadl, Awwad A. Radwan, Mohamed Attia, Abdullah Al-Dhfyan, Hatem A. Abdel-Aziz, Schiff Bases of Indoline-2,3-Dione (Isatin) with Potential Antiproliferative Activity, Chem. Cent. J., doi: 10.1186/1752-153X-6-49, Vol. 6, No. 1, p. 49, http://journal.chemistrycentral.com/content/pdf/1752-153X-6-49.pdf, 2012
14-Tarek Aboul-Fadl, Suliman S. Al-Hamad, Mohammed K. Abdel-Hamid, Hatem A. Abdel-Aziz, Abdel-Rahman M. Al-Obaid, Jason D. Whitt, Bernard D. Gary, Adam B. Keeton and Gary A. Piazza. , Novel amino acid derivatives of naproxen for colon cancer chemoprevention. , 243rd American Chemical Society meeting, San Diego, California -USA , ACS, 2012
15-Awwad A. Radwan, Abdullah Al-Dhfyan, Mohammed K. Abdel-Hamid, Abdullah A. Al-Badr, Tarek Aboul-Fadl, 3,5-Disubstituted Thiadiazine-2-thiones: New Cell-Cycle Inhibitors, Archives of Pharmacal Research , Springer International Publishing AG, Vol. 35, No. 1, 35-49, 2012
البحث كاملا
16-Tarek Aboul-Fadl, Awwad A. Radwan, Hatem A. Abdelaziz, Mohd. Baseeruddin, Mohamad I. Attia, Adnan Kadi, Novel Schiff Bases of Indoline-2,3-Dione and Nalidixic Acid Hydrazide: Synthesis, In Vitro Antimycobacterial and In Silico Mycobacterium Tuberculosis (Mtb) DNA Gyrase Inhibitory Activity, Digest Journal of Nanomaterials and Biostructures, Vol. 7, No. 1, pp. 327-336, http://www.chalcogen.infim.ro/329_Fadl.pdf, 2012
17-Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Abdul-Rahman M. Al-Obaid, Abdullah Al-Dhfyan and Alessandro Contini. , Design and Synthesis of substituted Nicotinic Acid Hydrazones With Potential Antiproliferative Activity. , The 66th Northwest Regional Meeting of The American Chemical Society (NORM 2011), Portland, Oregon-USA, American Chemical Society , 2011
18-Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Mohammed K. Abdel-Hamid, Tilal Elsaman, Jane Thanassi, Michael J. Pucci, Schiff Bases of Indoline-2,3-dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase., Molecules , Vol. 16, pp. 7864-7879, 2011
البحث كاملا
19-Tarek Aboul-Fadl, Mahmoud M. Sheha, Adel S. El-Azab, Hatem A. Abdel-Aziz, Amantadine Amides Prodrugs as Hepatic Delivery Systems to Enhance its Activity Against HCV, Digest Journal of Nanomaterials and Biostructures, the Academy of Romanian Scientists, Vol. 6, No. 4, pp. 1675-1683, http://www.chalcogen.infim.ro/1675_Fadl.pdf, 2011
20-Hoong-Kun Fun, Madhukar Hemamalini, Hatem A. Abdel-Aziz, Tarek Aboul-Fadl, (Z)-Ethyl 2-cyano-2-{2-[5,6-dimethyl-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]-pyridin-3-yl]-hydrazinylidene}acetate, Acta Cryst.,  doi: 10.1107/S1600536811028911, E67, pp. o2145-o2146 , journals.iucr.org/e/issues/2011/08/00/is2753/is2753.pdf, 2011
21-Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Adnan Kadi, Ahmed Bari, Pervez Ahmad, Tilal Al-Samani, Seik Weng Ng, Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids, Molecules, doi: 10.3390/molecules16053544, Vol.  16, pp. 3544-3551, http://www.mdpi.com/1420-3049/16/5/3544/, 2011
22-Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Adnan Kadi, Pervez Ahmad, Tilal Elsaman, Mohamed W. Attwa, Ibrahim A. Darwish, Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of a Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential Antimycobacterial Activity, Molecules, doi: 10.3390/molecules16065194, Vol. 16, pp. 5194-5206, http://www.mdpi.com/1420-3049/16/6/5194/, 2011
23-Jessica J. Kempe-Dustin, Tarek Aboul-Fadl, Clarissa Christensen, Robert Palais, Krishna Parsawar, Gerald J. Gleich, Lori A. Wagner, Cell Screening Assay for Identifying Inhibitors of Eosinophil Proliferation, Drug Dev. Res., DOI: 10.1002/ddr.20438, WILY, Vol. 72, pp. 353-360, http://onlinelibrary.wiley.com/doi/10.1002/ddr.20438/abstract, 2011
24-Wesam S. Abdel-Aal, Hoda Y. Hassan, Tarek Aboul-Fadl, Adel F. Youssef, Pharmacophoric Model Building for Antitubercular Activity of the Individual Schiff Bases of Small Combinatorial Library, European Journal of Medicinal Chemistry, vol. 45, pp. 1098 - 1106, 2010
25-Abdelwareth A. O. Sarhan, Abdullah Al-Dhfyan, Maha A. Al-Mozaini, Chaker N. Adra, and Tarek Aboul-Fadl, Cell Cycle Disruption and Apoptotic Activity of 3-Aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues, Eur. J. Med. Chem., Elsevier, 45, 2689-2694, 2010
26-Tarek Aboul-Fadl and Fayzah A. S. Bin-Jubair, Anti-Tubercular Activity of Isatin Derivatives. , Int. J. Res. Pharm. Sci. , 1(2), 113-126 , www.ijrps.pharmascope.org, 2010
27-Ibrahim A. Darwish, Tarek Aboul-Fadl, Nasr Y. Khalil, Ashraf M. Mahmoud, Abdul-Rahman M. Al-Obaid , New Sensitive HPLC Method for Evaluation of the Pharmacokinetics of New Amantadine Prodrugs as Hepatic Delivery Systems to Enhance its Activity against HCV, Int. J. Res. Pharm. Sci, 1(2), 151-157, www.ijrps.pharmascope.org, 2010
28-Tarek Aboul-Fadl, Fayzah A. S. Bin-Jubair and Omima Aboul-Wafa. , Schiff Bases of Indoline-2,3-dione (Isatin) Derivatives and Nalidixic Acid Carbohydrazide, Synthesis, Antitubercular Activity and Pharmacophoric Model Building. , Eur. J. Med. Chem., 45, 4578-4586, 2010
29-Wael M. El-Sayed, Tarek Aboul-Fadl and Michael R. Franklin. , Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and Chemoprotective Enzymes in Mice. , Drug Development Research , 71(5), 313-322, 2010
30-Tarek Aboul-Fadl, Hatem A. Abdul-Khader, Adnan Khadi, Ibrahim Darwish, Telal Al-Samani, Pervez Ahmad, Ahmed Bari and Sahal Al-Hajoj. , Design and Synthesis of a Combinatorial Library of Indoline-2,3-dione Schiff bases with Potential Anti-tubercular Activity. , 46th International Conference on Medicinal Chemistry (RICT 2010), Reims-France, June 30 -July 2, 2010., 2010
31-Fayzah A. S. Bint-Jubair, Omima Aboul-Wafa and Tarek Aboul-Fadl. , Schiff Bases of Indol-2,3-dione (Isatin) Derivatives and Nalidixic Acid Hydrazidewith Potential Antitubercular Activity. , The 8th Saudi International Pharmaceutical Conference and Exhibition, Riyadh-Saudi Arabia, April 26-28, 2010., 2010
32-Hatem A. Abdel-Aziz, AhmedBari, T. Aboul-Fadl and Seik Weng Ng. , (Z)-3Hydrazinylidene-1-phenylindolin-2-one. , Acta Crystallographica Section E, 66(11), o3014, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009040/?tool=pmcentrez, 2010
33- Wesam S. Abdel-Aal, Hoda Y.Hassan, Tarek Aboul-Fadl and Adel F. Youssef, Solution-Phase Synthesis of Small Schiff Bases Combinatorial Library with Potential Antitubercular Activity, Der Pharma Chemica, 1 (2), 1- 13, www.derpharmachemica.com, 2009
34- Ashraf M. Mahmoud, Nasr Y. Khalil, Ibrahim A. Darwish, Tarek Aboul-Fadl, Selective Spectrophotometric and Fluorometric Method for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with Sodium 1,2- Naphthoquinone-4-Sulphonate, Intl. J. Anal. Chem, Hindawi Publishing Corporation, 1-9, 2009
35-Ibrahim A. Darwish, Ashraf M. Mahmoud, Tarek Aboul-Fadl, Abdul-Rahman A. Al-Majed, Nasr Y. Khalil , A highly sensitive enzyme immunoassay for evaluation of 2_-deoxycytidine plasma level as a prognostic marker for breast cancer chemotherapy, Analytica Chimica Acta, 632, 266–271, 2009
36-Ahmed Galal, Safwat Ahmed, Ehab A. Abourashed, Desmond Slade, Waseem Gul, Shabana Khan, Tarek Aboul-Fadl and Mahmoud A. ElSohly., Antimicrobial and Estrogenic Activity of Ferutinin and Selected Semi-Synthetic Analogs. , The 50th Anniversary Meeting of the American Society of Pharmacognosy, Honolulu, HI-USA, June 27-July 1, 2009., 2009
37-Tarek Aboul-Fadl , Ashraf M. Mahmoud, Nasr Y. Khalil, Ibrahim A. Darwish and Abdul-Rahman Al-Obaid , Evaluation of The Pharmacokinetic of New Amantadine Prodrugs As Hepatic Delivery Systems to Enhance Its Activity Against HCV by A New HPLC Method. , 237th American Chemical Society meeting, Salt Lake City, Utah-USA, March 22-26, 2009., 2009
38- Ahmed Galal, Safwat Ahmed, Ehab A. Abourashed, Desmond Slade, Waseem Gul, Shabana Khan, Tarek Aboul-Fadl and Mahmoud A. ElSohly., Preparation, Antimicrobial and Estrogenic Activity of Ferutinin and Selected Analogs., The annual meeting of the National Center for Natural Products Research of the University of Mississippi, University of Mississippi-USA, January 2009., 2009
39-Wesam S. Abdel Aal, Hoda Youssef, *Tarek Aboul-Fadl, M.O. Khalid, Adel F. Youssef, Design, Synthesis and Antitubercular Evaluation of Small Schiff Base Combinatorial Library, The 7th International Saudi Pharmaceutical Conference, 2008
40-Tarek Aboul-Fadl, Gopalan Rajeev Kallanthottathil and Arthur D. Broom, Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-mercaptopurine Base, J. Heterocyclic Chem., 45, 445-451, 2008
41-Dorinda D Arch, Wael M El-Sayed, Tarek Aboul-Fadl, Jeannette C Roberts and Michael R Franklin , Regulation of ATP-binding cassette (Abc) transporters by organoselenium compounds, The FASEB , 22, 921, 2008
42-Tarek Aboul-Fadl, Selenium Derivatives as a Cancer Preventive Agents. , 2nd World Conference on Magic Bullets (Ehrlich II). Nürnberg, Germany, October 3 - 5, 2008. , 2008
43-M. R. Franklin, P. J. Moos, W. M. El-Sayed, T. Aboul-Fadl, J.C. Roberts , Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse , Chem-Biol Interactions, 168, 211–220, 2007
44-Wael M. El-Sayed, Tarek Aboul-Fadl, Jeanette C. Roberts, John G. Lamb and Michael R. Franklin, Murine Hepatoma (Hepa1c1c7) Cells: A Responsive In Vitro System for Chemoprotective Enzyme Induction by Organoselenium Compounds , Toxicology in Vitro, 21, 157-164, 2007
45-M.R. Franklin, J.C. Roberts, W.M. El-Sayed, T. Aboul-Fadl, T. Schofield, J.E. Constance and J.G. Lamb. , Chemoprevention in mice by 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids. , The 46th Annual Meeting (SOT), Charlotte, NC-USA, March 2007. , SOT, Abstract 609, Toxicological Sciences p126S., 2007
46-Wesam S. Abd-el Aal, Hoda Y. Hassan, Tarek Aboul-Fadl , Adel F. Youssef. , Design, Synthesis and Antitubercular Evaluation of Small Schiff Base Combinatorial Library. , The 7th International Saudi Pharmaceutical Conference. Riyadh-Saudi Arabia, March 19-21 2007. , Saudi Pharmaceutical Society, 2007
47-Tarek Aboul-Fadl, Antisense Oligonucleotide Technologies in Drug Discovery. , Expert Opin. Drug Discov, 1, 285-288, 2006
48- Maria Arballo, Latoya Cooks, Jenny Gomes, Tiara Williams, Tarek Aboul-Fadl and Jeanette Roberts, Sensitivity of Escherichia coli to L-selenaproline and other L-proline analogues in laboratory culture media and normal. human urine Charles Deutch., Letters in Applied Microbiology , 43, 392–398, 2006
49-Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts, and Michael R. Franklin. , Acute Effects of Novel Selenazolidines on Murine Chemoprotective Enzymes. , Chemico-Biological Interactions , 162, 31-42 , 2006
50-Abdel-Wareth A.O. Sarhan, Shams H. Abdel-Hafez, Hassan El-Sherif and Tarek Aboul-Fadl, The Utility and Synthetic Uses of Mannich Reaction: An efficient Route for Synthesis of Thiadiazino-[1,3,5][3,2-a]Benzimidazoles. , Synthetic Communications , 36, 987 - 996 , 2006
51-Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts, Michael R. Franklin , Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. , Toxicology, 220, 179–188 , 2006
52-Safwat M. Rabea, Nawal A. El-Koussi, Hoda Y. Hassan, Tarek Aboul-Fadl , Synthesis of 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives of Potential Anti-inflammatory Activity. , Arch. Pharm. Chem.Life Sci., 339, 32-40, 2006
53-Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin. , Effects of acute exposure of selenazolidines prodrugs of L-selenocysteine on chemoprotective enzymes in mice and Hepa1c1c7 cells. , The 45th Annual Meeting of the Society of Toxicology (SOT), San Diego, California-USA, March 5-9, 2006., SOT, 2006
54-Michael R. Franklin, Jeanette Roberts, Tarek Aboul-Fadl, Preparation of prodrugs and conjugates of thiol- and selenol-containing compounds. , U.S. Pat. Appl. Publ. , (Patent), 20 pp , 2005
55-Tarek Aboul-Fadl, Selenium Derivatives as Cancer Preventive Agents. ‘A Review Article’. , Current Medicinal Chemistry-Anti-Cancer Agents, 5, 637-52 , 2005
56-Tarek Aboul-Fadl, Antisense Oligonucleotides: The State of the Art ‘A Review Article’. , Current Medicinal Chemistry , 12, 2193-2214, 2005
57-Mostafa A. Hussein, Tarek Aboul-Fadl and Asmaa Hussein, Synthesis and Antitubercular Activity of Some Mannich bases Derived from Isatin Isonicotinic acid hydrazone. , Bull. Pharm. Sci., Assiut University, Assiut University, 28, 131-136 , 2005
58-Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin. , The biological effects of selenocysteine prodrugs. , Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-USA, September 9, 2005., 2005
59-C. E. Deutch, M. E. Arballo, L. N. Cooks, J. M. Gomes, T. M. Williams, T. Aboul-Fadl, and J. C. Roberts. , Uptake of L-Selenaproline by the L-Cystine Transport System in Escherichia coli., 105th General Meeting of the American Society for Microbiology, Atlanta, Georgia, USA, June 5-9, 2005., 2005
60-Tarek Aboul-Fadl, Wael M. El-Sayed, Tenley Schofield, Jonathan Constance, John G. Lamb, Jeanette C. Roberts, and Michael R. Franklin. , Hepatic effects of novel selenazolidine prodrugs of selenocysteine developed as potential cancer chemopreventive agents. , 229th ACS National Meeting, San Diego, California, USA, March 13-17, 2005. , ACS, 2005
61-Tarek Aboul-Fadl, Vijai K. Agrawal, Robert W. Buckheit Jr. and Arthur D. Broom, An Unusual “Senseless” 2’-5’ Oligoribonucleotide with Potent Anti-HIV Activity. , Nucleosides, Nucleotides & Nucleic Acids , 23, 545-554, 2004
62-Mostafa A. Hussein, Tarek Aboul-Fadl, Mahrous Osman, Mohamed Hassan and Mohamed Hashem. , Optical Isomers of 3-substituted-5-(2-carboxyethyl)-1,3,5- thiadiazin-2-thiones of Potential Antimicrobial Activity, Synthesis, and Solid State Stability. , Egyptian J. of Biomedical Sciences , 16, 194-209, 2004
63- Wael M. El-Sayed, Tarek Aboul-Fadl, Ronald B. McEwen, Tenley Schofield, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin. , Phase II Drug Metabolizing Enzyme mRNA Changes by Novel Selenazolidine Prodrugs of Selenocysteine in Mice., The 22nd Annual Meeting of the Mountain West Society of Toxicology (MWSOT), Park City – Utah, USA. September 9-10, 2004. , 2004
64-Tarek Aboul-Fadl, Fargany A. Mohammed and Ehssan A. Hassan , Synthesis, Antitubercular Activity and Pharmacokinetic Studies of Some Schiff Bases Derived from 1- Alkylisatin and Isonicotinic Acid Hydrazide (INH). , Archives of Pharmacal Research, 26, 778-784, 2003
65-Sahar Mahmoud, Tarek Aboul-Fadl, Mahmoud Sheha, Hassan H. Farag and Abdel-Maboud I. Mouhamed., 1,2-Dihydroisoquinoline-N-Acetic Acid Derivatives as New Carriers for Specific Brain Delivery I : Synthesis and Estimation of Oxidation Kinetics Using Multivariate Calibration Method., Arch. Pharm.Pharm. Med. Chem. , 336, 573-584, 2003
66-Sahar Mahmoud, Mahmoud Sheha, Tarek Aboul-Fadl, and Hassan H. Farag., 1,2-Dihydroisoquinoline-N-acetic acid Derivatives as New Carriers for Brain Specific Delivery II: Delivery of Phenethylamine as Model Drug. , Arch. Pharm.Pharm. Med. Chem., 336, 526-531, 2003
67- Mostafa Hussein, Tarek Aboul-Fadl and Asmaa Abdel-Nasser. , Synthesis and Antitubercular Activity of some Schiff Bases Derived from Mannich Bases of Isatin and Isonicotinic Acid Hydrazide (INH)., Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, KrakÓw, Poland 15-18 October 2003. , 2003
68-Tarek Aboul-Fadl, Vijai Agrawal, Robert W. Buckheit Jr and Arthur D. Broom. , 2Unusual “Senseless” 2’-5’ Oligoribonucleotide with a Potent Anti-HIV Activity. , The 1st International Congress of Pharmaceutical and Drug Industries Division, National Research Center, Cairo-Egypt, March 24-26(2003)., 2003
69-Aboul-Fadl, T. and Khallil, A. M. , Synthesis, degradation kinetics and in-vitro antimicrobial activity of tetrahydro-2H-1,3,5-thiadiazine-2-thion derivatives of some B-amino acids. , Arzneim. Forsch. Drug Res. , 53 (7):, 526 – 531., 2003
70- Tarek Aboul-Fadl and Abdel-Raouf Khallil., Synthesis, Degradation kinetics and In-vitro Antimicrobial Activity of Tetrahydro-2H-1,3,5- thiadiazine-2-thione Derivatives of Some b-Amino Acids., Arzneim-Forsch./Drug Res., 526-531, 2002
71-Tarek Aboul-Fadl and Mahrous Osman., Tetrahydro-2H-1,3,5- thiadiazin-2-thione Derivatives of The optical Isomers of Phenylalanine, Synthesis, Comparative Stability Study and Antifungal Activity. , Sci. Pharm., 70, 359-378, 2002
72-Tarek Aboul-Fadl, Mostafa A. Hussein, Abdel-Nasser El-Shorbagi, and Abdel-Raouf Khallil., New 2H-Tetrahydro-1,3,5-thiadiazine-2-thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents. , Arch. Pharm.Pharm. Med. Chem. , 335, 438-442, 2002
73-Mostafa I. Abd-Elrahman, Mahrous O. Ahmed, Sayed M. Ahmed, Tarek Aboul-Fadl and A.El-Shorbagi. , Kinetics of solid state stability of glycine derivatives as a model for peptides using differential scanning calorimetry. , Biophysical chemistry., 19, 113-20, 2002
74-Stefan Löber, Tarek Aboul-Fadl, Harald Hübner and Peter Gmeiner. , Di- and Trisubstituted Pyrazolo[1,5-a]pyridine Derivatives: Synthesis, Dopamine Receptor Binding and Ligand Efficacy. , Bioorganic and Medicinal Chemistry Letters, 12, 633-636, 2002
75-Tarek Aboul-Fadl, K.G. Rajeev and A.D. Broom., Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-thiopurine Base. , 223 ACS meeting, Orlando, Florida-USA, April 6-11 (2002)., ACS, 2002
76- Sahar M. Mohamoud, Mahmoud M. Sheha, Tarek Aboul-Fadl and Hassan H. Farag., 1,2-Dihydroisoquinoline Derivatives as New Carrier for Brain Specific Delivery., Assiut University Third Pharmaceutical Sciences Conference, Assiut-Egypt, March 5-6 (2002), 2002
77- M.A. Hussein and T. Aboul-Fadl., Synthsis of New Optically Active Thiadiazine-2-thione Derivatives as Antifungal Agents., 8th IBN SINA Intrnational Conference on Pure and Apllied Heterocyclic Chemistry, Luxor-Egypt, Feb. 16-19 (2002)., 2002
78-Atef A. Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura, Masao Hattori, Mahmoud A. El-Gendy, Nadia M. Mahfouz and Tarek A. Mohamed. , New Paeonilactone-A-Adducts Formed by Incubation of Paeoniflorin with Lactobacillus brevis in Presence of Arylthiols. , Chem. Pharm. Bull. , 49, 918-920, 2001
79-Ahmed K. Dyab and Tarek Aboul-Fadl. , Antigiardial Activity of Metronidazole Twin Ester Prodrugs. , Zagazig University Medical Journal, VII(5), 1268-1275, 2001
80-T. Aboul-Fadl, M.A. Hussein and A. A. El-Shorbagi., Synthesis and Antifungal Activity of Some New 3,5-Disubstiuted Tetrahydro-2H-1,3,5-Thiadiazine-2-Thione., XXVII Conference of Egyptian Pharmaceutical Society, Cairo - Egypt, January 2-4 (2001., 2001
81- T. Aboul-Fadl, S. Löber and P. Gmeiner., Synthesis of 7-Substituted 3-[4(4-Chlorophenyl)-Piperazin-1-ylmethyl]-Pyrazolo[1,5-a]Pyridine Derivatives as Potential D4-Receptor Ligands., XXVII Conference of Egyptian Pharmaceutical Society, Cairo - Egypt, January 2-4(2001)., 2001
82-Tarek Aboul-Fadl, Abdel-Nasser El-Shorbagi, Zeinab A. Hozien and Abdel-Wareth A.O. Sarhan. , Investigation of Alkylating, Antineoplastic and Anti-HIV Potentials of the Chalcones; 2-(3-Arylpropenoyl)benzimidazole and Their Corresponding N1-Methyl Derivatives. , Bollettino Chimico Farmaceutico. , 139, 228-234, 2000
83-Tarek Aboul-Fadl, Stefan Löber and Peter Gmeiner. , Effective and Variable Functionalization of Pyrazolo[1,5-a]pyridines Involving Palladium-Catalyzed Coupling Reactions. , Synthesis , 12, 1727-1732, 2000
84-F.A. Omar, N. M. Mahfouz and T. Aboul-Fadl. , Cyclic amide derivatives as potential prodrugs: N-hydroxymethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. , Eur. J. Med. Chem., 34, 551-562, 1999
85-A. A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, Y. Murakami. M. A. El-Gendy, N. M. Mahfouz and T. A. Mohamed., Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis. , Biol. Pharm. Bull., 22, 491-497, 1999
86-T. Aboul-Fadl and K. Hassanin. , Tetrahydro-2H-1,3,5-thiadiazin-5-(4-pyridylcarboxamide)-2-thione Derivatives as prodrugs for Isoniazid, Synthesis, Investigations and In Vitro Antituberculous Activity. , Pharmazie , 54, 244-247, 1999
87-T. Aboul-Fadl, M. M. Sheha and S. Khider. , Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis, Characterization and in vitro Stability. , Sci. Pharm. , 67, 27-41, 1999
88-T. Aboul-Fadl and N. M. Mahfouz. , Metronidazole Twin Ester Prodrugs II : Non Identical Twin Esters of Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline Derivatives. , Sci. Pharm., 66, 309-324, 1998
89-A.A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, Y. Murakami, M. A. El-Gendy, N. M. Mahfouz and T. A. Mohamed., Effects of Paeoniflorin Derivatives on the Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship. , Biol.Pharm.Bull., 21, 1174-1174, 1998
90-Ahmed.K. Diab.N. M. Mahfouz, T. Aboul-Fadl and A. K. Diab., Esters Twin Drugs of Metronidazole : Synthesis, Physicochemical properties, Kinetic studies and Antigardial activity. , Eur. J. Med. Chem. , 33, 675-683, 1998
البحث كاملا
91-T.A. Fadl and F. A. Omar. , Paracetamol (Acetaminophen) Esters of Some Non-steroidal Anti-inflammatory Carboxylic acids Drugs as Mutual Prodrugs with Improved Therapeutic Index. , Inflammopharmacology , 6, 143-157, 1998
92-A.A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, T. A. Mohamed, N. M. Mahfouz and M. A. El-Gendy. , Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by Incubation of Paeoniflorin and Sulfhydryl Compounds With Lactobacillus Brevis., Chem.Pharm. Bull., 46, 1486-1487, 1998
93- T. Aboul-Fadl, M. M. Sheha and S. Khider., Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis, Characterization and in vitro Stability., XXVI Conference of Egyptian Pharmaceutical Society, Cairo- Egypt, December 8-10(1998), 1998
94- S. Emara and T. Aboul-Fadl., Flow injection analysis of amino acids using Cu(II) oxide as a packed reactor for ultraviolet detection., Fourth European Congress of Pharmaceutical Sciences, Milan-Italy, September 11-13(1998)., 1998
95-F. A. Omar, N. M. Mahfouz and T. Aboul-Fadl. , Cyclic amide derivatives as potential prodrugs: N-hydroxmethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. , XIV Scientific Meeting of the Austrian Pharmaceutical Society, Graz - Austria, June 11-13(1998)., 1998
96-T. Aboul-Fadl, W. Fleischhacker and E. Urban. , A Structurally Simplified Analogue of the Antibiotic Heptelidic Acid With a Five Membered Carbocyclic Ring. , XIV Scientific Meeting of the Austrian Pharmaceutical Society, Graz -Austria, June 11-13(1998), 1998
97-Ahmed. K. Diab.T. Aboul-Fadl, N. M. Mahfouz and A. K. Diab., Metronidazle Twin Esters Prodrugs II : Non Identical Twin Esters of Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline Derivatives., Assiut University First International Pharmaceutical Sciences Conference, Faculty of Pharmacy, Assiut-Egypt, March 4-5(1998) , 1998
98-aAhmed diab, Tarek aboel fasdel and Nadea M. mohafoz, metronidazole twin ester prodrugs : synthesis , physicchemical properties , hydrolysis kinetic and antigardial activity , Eur.J.Med. Chem. , 33.675, 675, 1998
البحث كاملا
99-T. Aboul-Fadl and A. El-Shorbagi. , New Carriers for Representative Peptide Drugs. , Arch. Pharm.Pharm. Med. Chem. , 330, 327- 332, 1997
100-Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, T. A. Mohamed, N. M. Mahfouz and M. A. El-Gendy. , Modifications of Paeoniflorin and Paeonimetabolin I by Chemical and Biochemical Means. , International Symposium on Natural Medicines, Kyoto - Japan, October 28 -30(1997), 1997
101-T. Kawaguchi, A.F.Youssef, T.Aboul-Fadl, F.A.Omar, H.H.Farag, and T.Hasegawa., Steric Parameters in PLE Catalyzed Hydrolysis of N4-substituted Cytarabine Esters Prodrugs. , Pharmazie, 51, 717-719, 1996
102-T.Aboul-Fadl and A. El-Shorbagi., New Prodrug Approach for Amino Acids and Amino-Acid-Like Drugs. , Eur. J. Med. Chem., 31, 165-169, 1996
103-T. Aboul-Fadl and E. A. Fouad., Synthesis and In Vitro Investigation of Nalidixic Acid Amides of Amino Acid Esters as Prodrugs. , Pharmazie, 51, 30-33, 1996
104-T. Aboul-Fadl and A. El-Shorbagi., Tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives as new carriers for peptide drugs. , XXV Conference of Egyptian Pharmaceutical Society, Cairo- Egypt, December 24-26(1996), 1996
105-T.A.Fadl, T.Hasegawa, A.F.Youssef, H.H.Farag, F.A.Omar and T.Kawaguchi., Synthesis and Investigation of N4-substituted Cytarabine Derivatives as Prodrugs. , Pharmazie, 50, 382-387, 1995
106-T. Aboul-Fadl, A. El-Shorbagi, Z. Hozein and A. Sarhan. , Synthesis and Investigation of the Alkylating Potential of 2-(3-Arylpropen-oyl)benzimidazole and their Corresponding N1-methyl Derivatives. , Al-Azhar First International Conference on Recent Advances in Pharmaceutical Technology and Biological Sciences, Cairo - Egypt, December 19-21(1995), 1995
107- T.Abo-El-Fadl, A. F. Youssef and A. N. Ahmed, 1HNMR and chelating properties of 1,5-dimethyl-N-substituted-1H-pyrazole-3- carboxamides and 1,3-dimethyl-N-substituted-1H-pyrazole-5-carboxamides., Pharmazie, 48, 117-120, 1993
108- T.A.Fadl, T.Hasegawa, A.F.Youssef, H.H.Farag, F.A.Omar and T.Kawaguchi., Synthesis, Hydrolysis Kinetics, Lipophilicity, and Biological Activity of N4-(3-Alkoxy and Benzyloxycarbonylpropionyl)-Ara-C Prodrugs., World congress of Pharmacy and Pharmaceutical Sciences "FIP'93", Tokyo, Japan, September 5-10(1993), 1993
109- T.A. Mohamed, A. F. Youssef and A. N. Ahmed, 1HNMR of Pyrazoles : effect of interaction of carbamoyl group with adjacent centers on the chemical shifts of concerned protons., Bull. Pharm. Sci., Assiut University, 15, 100-105, 1992
110-T.A. Fadl, A. F. Youssef, A. N. Ahmed., 1HNMR and chelating properties of 1,5-dimethyl-N-substituted -1H- pyrazole-3-carboxamides and 1,3-dimethyl-N-substituted-1H- pyrazole-5-carboxamides., 3rd IBN SINA Symposium on Heterocyclic Chemistry, Aswan, Egypt, January 28-31(1991), 1991
111- T.A. Fadl, A. F. Youssef, A. N. Ahmed and H. I. El-Bitar., Synthesis and Biological activity of certain 1,3- and 1,5-dimethyl-N-substituted pyrazole carboxamides., Bull. Pharm. Sci., Assiut University , 13, 145-158, 1990
112- T. A. Fadl and F. A. Omar. , Acetaminophen Esters of Some Non-steroidal Antiinflammatory Drugs as Mutual Prodrugs with Improved Therapeutic Index., Assiut University First International Pharmaceutical Sciences Conference, Faculty of Pharmacy, Assiut-Egypt, March 4-5(1998), 1968
الاشراف على رسائل الماجستير و الدكتوراه :
1- سليمان بن سعود بن سليمان الحمد, أميدات بعض مضادات الإلتهابات الغير إسترويدية كأدوية كامنة: تصميم وتشييد وتوصيف وتقييم فارماكولوجى, دكتوراة, 25-04-2012
المشرفون : أ.د. طارق أبوالفضل أ.د. عبدالرحمن العبيد
2- فايزة بنت أحمد بن جبير, تشييد بعض قواعد شيف لمشتقات الإندولين-2,3- دايون وكينولات حمض الكاربوكسيل ذات الفاعلية المحتملة كمضادات للدرن, ماجستير, 07-01-2009
المشرفون : طارق أبوالفضل محمد أميمة أبوالوفا
3- وسام صابر عبد العال, تصميم وتشييد مكتبة توافقية صغيرة من قواعد شييف وتقييمها كمضادات للدرن , ماجستير, 30-12-2007
المشرفون : عادل فوزي يوسف - طارق أبو الفضل محمد - هدى يوسف حسن
4- سهيلة فتحى حسن على, دراسات عن الهيستامين فى بعض منتجات اللحوم المباعة فى مدينة أسيوط, دكتوراة, 01-04-2004
المشرفون : أ.د. شوكت محمد فتحى أ.د. صباح إبراهيم أحمد أ.د. طارق أبوالفضل
5- سحر محمود محمد احمد, مشتقات 1‚2-ثنائى هيدروايزوكينولين-ن-حمض خليك كموصلات تفاضلية للادوية للمخ , ماجستير, 02-02-2003
المشرفون : حسن حسن فرج - طارق ابو الفضل محمد - محمود محمد محمد شيحة
6- عاطف عبدالمنعم عبدالحافظ, دكتوراة, 21-03-1999
المشرفون : طارق أبوالفضل
الجوائز :
1 - جائزة الشركة العربية للصناعات الدوائية والمستلزمات الطبية فى العلوم الصيدلية عام 2012.

عدد المقرارات5 مقرر
PHC 610
كيمياء طبية 2 (صيدلة إكلينيكية ----كلية الصيدلة قسم الكيمياء الطبية
PHC 415
كيمياء طبية 1 ----كلية الصيدلة قسم الكيمياء الطبية

الكيمياء العضوية المتقدمة ----كلية الصيدلة قسم الكيمياء الطبية

درجات أعمال السنة والعملي للفرقة الرابعة ----كلية الصيدلة قسم الكيمياء الطبية

درجات أعمال السنة والعملي للفرقة الثالثة ----كلية الصيدلة قسم الكيمياء الطبية