عودة

 

الدكتور / رفعت بكر حامد فرغل
أستاذ مساعد بقسم العقاقير، كلية الصيدلة، جامعة أسيوط
تفاصيل السيرة الذاتية
بيانات ال MIS دخول الإعضاء تواصل مع العضو نسخة للطباعة
العنوان الحالى قسم العقاقير - كلية الصيدلة - جامعة أسيوط - أسيوط – مصر
تليفون المكتب +20882411268
تليفون المنزل +20932584564
الفاكس +20882080774
البريد الالكترونى r.hamed@aun.edu.eg
r.hamed@aun.edu.eg
الموقع الالكترونى https://www.linkedin.com/in/refaathamed?trk=nav_responsive_tab_profile
google scholar link http://scholar.google.com/citations?user=IvcUMmwAAAAJ&hl=en
  • دكتوراه، 2010
  • ماجستير فى العلوم الصيدلية ( العقاقير ) ، كلية الصيدلة، جامعة أسيوط، 2004
  • بكالوريوس فى العلوم الصيدلية، كلية الصيدلة، جامعة أسيوط، 1999
الدرجات العلمية :
  • أستاذ مساعد بقسم العقاقير، كلية الصيدلة، جامعة أسيوط، 2016
  • مدرس بقسم العقاقير، كلية الصيدلة، جامعة أسيوط، 2011
  • مدرس مساعد بقسم العقاقير، كلية الصيدلة، جامعة اسيوط، 2004
  • معيد بقسم العقاقير، كلية الصيدلة، جامعة أسيوط، 1999
المناصب الادارية :
المناصب السابقة :
مدير وحدة الخدمات التكنولوجية، كلية الصيدلة، جامعة أسيوط, في الفترة من (07-2014 إلى 01-2016 )

المجالات البحثية:
Biosynthesis , Biocatalysis , Protein Engineering , Mechanistic Enzymology , Antibiotic Resistance and Synthetic Biology

الابحاث :

1-TristanJ.Smart,Refaat B.Hamed,Timothy D.W.Claridge,ChristopherJ.Schofield, Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles, Bioorganic Chemistry, ELSEVIER, 94, 103386, 1-9, https://www.sciencedirect.com/science/article/pii/S0045206819312222, January, 2020
البحث كاملا
2-Refaat B. Hamed, J. Ruben Gomez-Castellanos, Luc Henry, Sven Warhaut, Timothy D. W. Claridge & Christopher J. Schofield , Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases, Communications Chemistry, Springer Nature, 2:7, 1-10, https://www.nature.com/articles/s42004-018-0106-z, January, 2019
البحث كاملا
3-Sharma, S. V. Tong, X. Pubill-Ulldemolins, C. Cartmell, C. Bogosyan, E. J. A. Rackham, E. J. Marelli, E. Hamed, R. B. Goss, R. J. M., Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo, Nature Communications, 8, 229, https://www.nature.com/articles/s41467-017-00194-3, August, 2017
4-Christopher Thomas Lohans, David Y. Wang, Jimmy Wang, Refaat B. Hamed, and Christopher J. Schofield, Crotonases - Nature's Exceedingly Convertible Catalysts, ACS Catalysis, American Chemical Society, 10.1021/acscatal.7b01699, http://pubs.acs.org/doi/abs/10.1021/acscatal.7b01699, August, 2017
5-Refaat Bakr Hamed, Luc Henry, Timothy D. W. Claridge, and Christopher J. Schofield, Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes, ACS Catalysis, American Chemical Society, 10.1021/acscatal.6b02509, http://pubs.acs.org/doi/abs/10.1021/acscatal.6b02509?journalCode=accacs, January, 2017
البحث كاملا
6-Refaat B. Hamed, J. Ruben Gomez-Castellanos, D. Sean Froese, Ewelina Krysztofinska, Wyatt W. Yue and Christopher J. Schofield, Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity, ChemBioChem, Wiley, Voume 17, Issue 6, 471-473, http://onlinelibrary.wiley.com/doi/10.1002/cbic.201500644/abstract?systemMessage=Subscribe+and+renew+is+currently+unavailable+online.+Please+contact+customer+care+to+place+an+order%3A++http%3A%2F%2Folabout.wiley.com%2FWileyCDA%2FSection%2Fid-397203.html++, March, 2016
7-Refaat B. Hamed, J. Ruben Gomez-Castellanos, Luc Henry1, Christian Ducho, Michael A. McDonough, Christopher J. Schofield, The Enzymes of β-Lactam Biosynthesis, Nat. Prod. Rep., DOI: 10.1039/c2np20065a, Vol. 30, pp. 21-107, 2013
8-Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Amina Asghar, Jürgen Brem, Timothy D. W. Claridge, Christopher J. Schofield, Stereoselective Preparation of Lipidated Carboxymethylproline / Pipecolic Acid Derivatives via Coupling of Engineered Crotonases with an Alkylmalonyl-CoA Synthetase, Org. Biomol. Chem., DOI: 10.1039/c3ob41525b, Vol. 11, pp. 8191-8196 , http://pubs.rsc.org/EN/content/articlehtml/2013/ob/c3ob41525b, 2013
9-Wei Ge, Alexander Wolf, Tianshu Feng, Chia-hua Ho, Rok Sekirnik, Adam Zayer, Nicolas Granatino, Matthew E Cockman, Christoph Loenarz, Nikita D Loik, Adam P Hardy, Timothy D W Claridge, Refaat B Hamed, Rasheduzzaman Chowdhury, Lingzhi Gong, , Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans, NATURE CHEMICAL BIOLOGY, Volume 8, Issue 12, 960-962, http://www.nature.com/nchembio/journal/v8/n12/full/nchembio.1093.html, December, 2012
10-Monica Mantri, Celia J. Webby, Nikita D. Loik, Refaat B. Hamed, Michael L. Nielsen, Michael A. McDonough, James S. O. McCullagha, Angelika Böttgerd, Christopher J. Schofield, Alexander Wolf, Self-Hydroxylation of the splicing factor lysyl hydroxylase, JMJD6, MedChemComm, 3, 80-85, 2012
11-Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Jasmin Mecinović, Christian Ducho, John L. Sorensen, Timothy D. W. Claridge, Christopher J. Schofield, Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams, J. Am. Chem. Soc., Vol. 134, PP. 471–479, http://pubs.acs.org/doi/abs/10.1021/ja208318d, 2012
12-Ming Yang, Rasheduzzaman Chowdhury, Wei Ge, Refaat B. Hamed, Michael A. McDonough, Timothy D. W. Claridge, Benedikt M. Kessler, Matthew E. Cockman, Peter J. Ratcliffe, Christopher J. Schofield, Factor-Inhibiting Hypoxia-Inducible Factor (FIH) Catalyses the Post-Translational Hydroxylation of Histidinyl Residues within Ankyrin Repeat Domains, FEBS Journal, doi:10.1111/j.1742-4658.2011.08022.x, Vol. 278, PP. 1086-1097, 2011
13-Monica Mantri, Nikita D. Loik, Refaat B. Hamed, Timothy D. W. Claridge, James S. O. McCullagh, Christopher J. Schofield, The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues, ChemBioChem, doi: 10.1002/cbic. 201000641, Vol. 12, PP. 531-534, 2011
14-Dante Rotili, Mikael Altun, Refaat B. Hamed, Christoph Loenarz, Armin Thalhammer, Richard J. Hopkinson, Ya-Min Tian, Peter J. Ratcliffe, Antonello Mai, Benedikt M. Kessler, Christopher J. Schofield, Photoactivable Peptides for Identifying Enzyme–Substrate and Protein–Protein Interactions, Chem. Commun,doi: 10.1039 /c0cc04457a, Vol. 47, No. 5, PP. 1488-1490, 2011
15-Refaat B. Hamed, J. Ruben Gomez-Castellanos, Armin Thalhammer, Daniel Harding, Christian Ducho, Timothy D. W. Claridge, Christopher J. Schofield, Stereoselective C–C Bond Formation Catalysed by Engineered Carboxymethylproline Synthases, Nature Chemistry, Nature Publishing Group, Vol. 3, PP. 365-371, doi: 10.1038/nchem.1011, 2011
16-Refaat B. Hamed, Jasmin Mecinović, Christian Ducho, Timothy D. W. Claridge, Christopher J. Schofield, Carboxymethylproline Synthase Catalysed Syntheses of Functionalised N-Heterocycles, Chem. Commun., DOI: 10.1039/B924519G, Vol. 46, pp. 1413-1415, January, 2010
17-Schofield C. J., Hamed R. B., Batchelar E. T., Ducho C., Methods for preparing heterocyclic rings, (Organization, W. I. P., Ed.)., WO Patent WO, 2010
18-Richard J. Hopkinson, Refaat B. Hamed, Nathan R. Rose, Timothy D. W. Claridge, Christopher J. Schofield, Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde, ChemBioChem., DOI: 10.1002/cbic.200900713, Vol. 11, pp. 506 - 510, 2010
19-Emily Flashman, Lee M. Hoffart, Refaat B. Hamed, J. Martin Bollinger Jr, Carsten Krebs, Christopher J. Schofield, Evidence for the Slow Reaction of Hypoxia- Inducible Factor Prolyl Hydroxylase 2 with Oxygen, FEBS Journal, Vol. 277, pp. 4089 - 4099, 2010
20-Jasmin Mecinović, Refaat B. Hamed, Christopher J. Schofield, Iron-Mediated Cleavage of C-C Bonds in Vicinal Tricarbonyl Compounds in Water, Angew. Chem. Int. Ed., DOI: 10.1002/anie.200806296, Vol. 48, pp. 2796 - 2800, 2009
21-Refaat B. Hamed, Edward T. Batchelar, Jasmin Mecinović, Timothy D. W. Claridge, Christopher J. Schofield, Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline, ChemBioChem., DOI: 10.1002/cbic.200800652, Vol. 10, pp. 246 - 250 , 2009
22-Christian Ducho, Refaat B. Hamed, Edward T. Batchelar, John L. Sorensen, Barbara Odell, Christopher J. Schofield, Synthesis of Regio- and Stereoselectively Deuterium-Labelled Derivatives of L-Glutamate Semialdehyde for Studies on Carbapenem Biosynthesis, Org. Biomol. Chem., DOI: 10.1039/B903312B, Vol. 7, pp. 2770 - 2779, 2009
23-Refaat B. Hamed, Edward T. Batchelar, Clifton I. J., Christopher J. Schofield, Mechanisms and Structures of Crotonase Superfamily Enzymes – How Nature Controls Enolate and Oxyanion Reactivity, Cell. Mol. Life Sci., DOI: 10.1007/s00018-008-8082-6, Vol. 65, pp. 2507 - 2527, 2008
24-Edward T. Batchelar, Refaat B. Hamed, Christian Ducho, Timothy D. W. Claridge, Mariola J. Edelmann, Benedikt Kessler, Christopher J. Schofield, Thioester Hydrolysis and C-C Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily, Angew. Chem. Int. Ed., DOI: 10.1002/anie.200803906, Vol. 47, pp. 9322 - 9325 , 2008
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