As global energy demand continues to rise, the imperative to explore and enhance energy generation from existing resources intensifies. Combined cycle power plants (CCPPs) have emerged as a promising solution to improve efficiency and electricity production. In this study, we present a comprehensive analysis of the thermodynamic performance of a 750 MW CCPP located in Assiut, Egypt, with a focus on its energy and exergy efficiency. Our investigation reveals critical insights into the CCPP's operational dynamics. Notably, the combustion chambers emerge as the primary contributors to exergy destruction, accounting for 53.3 % of the total exergy loss. Heat recovery steam generators (HRSGs) follow closely at 32 %, while compressors, steam turbines, gas turbines, and cooling systems contribute 5.3 %, 5 %, 2.3 %, and 1.7 %, respectively. These findings pinpoint specific areas where exergy losses are most significant, offering valuable guidance for targeted improvements in CCPP performance. Furthermore, we report that the overall energy efficiency of the entire plant stands at 34.6 %, with an exergy efficiency of 33.5 %. In summary, our study provides a comprehensive scientific assessment of the thermodynamic performance of a 750 MW CCPP. The specific insights into exergy destruction and efficiency metrics not only contribute to our understanding of CCPPs but also offer actionable recommendations for optimizing the operation of gas turbine based CCPPs. These findings hold significance in the broader context of energy sustainability and environmental considerations.