Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis. ¹Department of OB-GYN, Cleveland Clinic Foundation, Cleveland, Ohio, USA; and ²Department of OB-GYN, Women’sHealth Centre, Assiut University, Assiut, Egypt

Faculty of Medicine

Assiut University

Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis.

¹Department of OB-GYN, Cleveland Clinic Foundation, Cleveland, Ohio, USA; and ²Department of OB-GYN, Women’sHealth Centre, Assiut University, Assiut, Egypt

Research Authors
Bedaiwy MA1, Noriega J1, Abdel Aleem M², Gupta S1, AbulHassan AM², Brainard J1, Ismail AM², Falcone T1.
Research Department
Department of Obstetrics and Gynecology
Research Journal
Analytical and Quantitative Cytology and Histology 2012 Feb;34(1):23-7
Research Member
Mahmoud Ahmed Mahmoud Abdel-Aleem
Research Rank
1
Research Year
2012
Research Abstract

ABSTRACT
OBJECTIVE: To evaluate peritoneal fluid hemosiderin-laden macrophages (H-LMs) in patients with endometriosis compared to controls.
STUDY DESIGN: Consecutive series of 46 patients during a year undergoing laparoscopy for benign gynecologic conditions were included. The presence of H-LMs in peritoneal fluid was evaluated. We compared clinical factors in patients with or without endometriosis in respect to H-LM status. To assess the potential of H-LMs to diagnose endometriosis, the sensitivity and specificity were calculated.
RESULTS: Patients with endometriosis were significantly more likely to have positive H-LM test results than controls (p = 0.0013). The presence of H-LM has a low sensitivity of 52% but an acceptable specificity of 87% in diagnosing endometriosis. The presence of H-LMs was not related with any other of the clinical factors studied.
CONCLUSION: The presence of specific findings of H-LMs related to endometriosis strongly suggests abnormalities in peritoneal iron metabolism.