Dr. Mahmoud Fahmy Ali Elsabahy

Director of Assiut International Centre for nano drugs Rajhi liver Hospital ، Assiut University
Associate Professor, Department of Pharmaceutics , Faculty of Pharmacy, ِِAssiut University

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Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Educational Qualifications:
  • Ph. D. In Pharmaceutical Sciences ( Pharmaceutics ) , University of Montreal, Canada, 2010
  • B. Sc. In Pharmaceutical Sciences, Faculty of Pharmacy, Assiut University, 2003
  • Associate Professor, Department of Pharmaceutics , Faculty of Pharmacy, ِِAssiut University, 2015
  • Lecturer, Department of Pharmaceutics , Faculty of Pharmacy, Assiut University, 2010
  • Demonstrator, Department of Pharmaceutics , Faculty of Pharmacy, Assiut University, 2003

Current Position :

  • Director of Assiut International Centre for nano drugs Rajhi liver Hospital , since September 2012
  • Past Positions :

  • Deputy Director the Center for Drug Research, from November 2013 to May 2018
  • Research fields:


    1 - Safy Hadiya, Xiaoqiang Liu, Wegdan Abd El-Hammed, Mahmoud Elsabahy, Sherine A Aly , Levofloxacin-Loaded Nanoparticles Decrease Emergence of Fluoroquinolone Resistance in Escherichia coli, Microbial Drug Resistance,, February, 2018
    2 - Heba A. Fathi, Ayat Allam, Mahmoud Elsabahy, Gihan Fetih and Mahmoud El-Badry, Nanostructured Lipid Carriers for Improved Oral Delivery and Prolonged Antihyperlipidemic Effect of Simvastatin, Colloids and Surfaces B: Biointerfaces, Vol. 162, pp. 236-245,, 2018
    3 - Helmy A.M., Elsabahy M., Soliman G.M., Mahmoud M.A. and Ibrahim E.A, Development and In Vivo Evaluation of Chitosan Beads for the Colonic Delivery of Azathioprine for Treatment of Inflammatory Bowel Disease, Eur. J. Pharm. Sci., DOI: 10.1016/j.ejps.2017.08.025, Vol. 109, pp. 269-279, 2017
    4 - Fuwu Zhang, Shiyi Zhang, Stephanie F. Pollack, Richen Li, Amelia M. Gonzalez, Jingwei Fan, Jiong Zou, Sarah E. Leininger, Adriana Pavía-Sanders, Rachel Johnson, Laura D. Nelson, Jeffery E. Raymond, Mahmoud Elsabahy, Dennis M. P. Hughes, Mark W. Lenox, Tiffany P. Gustafson, Karen L. Wooley, Improving Paclitaxel Delivery: In Vitro and In Vivo Characterization of PEGylated Polyphosphoester-Based Nanocarriers, J. Am. Chem. Soc., DOI: 10.1021/ja512616s, Vol. 137, pp. 2056-2066, 2015
    5 - Mahmoud Elsabahy and Karen L. Wooley, Data Mining as a Guide for the Construction of Cross-Linked Nanoparticles with Low Immunotoxicity via Control of Polymer Chemistry and Supramolecular Assembly, Acc. Chem. Res., DOI: 10.1021/acs.accounts.5b00066, Vol. 48, pp. 1620-1630, 2015
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    6 - Mahmoud Elsabahy, Gyu Seong Heo, Soon-Mi Lim, Guorong Sun and Karen L. Wooley, Polymeric Nanostructures for Imaging and Therapy, Chem. Rev., DOI: 10.1021/acs.chemrev.5b00135, Vol. 115, pp. 10967-11011, 2015
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    7 - Jiong Zou, Fuwu Zhang, Shiyi Zhang, Stephanie F. Pollack, Mahmoud Elsabahy, Jingwei Fan, Karen L. Wooley, Poly(ethylene oxide)-block-Polyphosphoester-graft-Paclitaxel Conjugates with Acid-Labile Linkages as a pH-Sensitive and Functional Nanoscopic Platform for Paclitaxel Delivery, Adv. Healthcare Mater., DOI: 10.1002/adhm.201300235 , Vol. 3, No. 3, pp. 441-448, 2014
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    8 - Young H. Lim, Gyu Seong Heo, Yohannes H. Rezenom, Stephanie Pollack, Jeffery E. Raymond, Mahmoud Elsabahy, Karen L. Wooley, Development of a Vinyl Ether-Functionalized Polyphosphoester as a Template for Multiple Postpolymerization Conjugation Chemistries and Study of Core Degradable Polymeric Nanoparticles, Macromolecules,, Vol. 47, pp. 4634-4644, 2014
    9 - Mahmoud Elsabahy, Shiyi Zhang, Fuwu Zhang, Zhou J. Deng, Young H. Lim, Hai Wang, Perouza Parsamian, Paula T. Hammond, Karen L. Wooley, Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles, Scientific Reports, DOI: 10.1038/srep03313, Vol. 3, 3313, pp. 1-10, 2013
    10 - Mahmoud Elsabahy, Ang Li, Fuwu Zhang, Deborah Sultan, Yongjian Liu, Karen L. Wooley, Differential Immunotoxicities of Poly(ethylene glycol)- vs. Poly(carboxybetaine)-Coated Nanoparticles, Journal of Controlled Release,, Vol. 172, pp. 641-652, 2013
    11 - Mahmoud Elsabahy, Sandani Samarajeewa, Jeffery E. Raymond, Corrie Clark, Karen L. Wooley, Shell-Crosslinked Knedel-like Nanoparticles Induce Lower Immunotoxicity than their Non-Crosslinked Analogs, Journal of Materials Chemistry B, DOI: 10.1039/c3tb20668h, Vol. 1, pp. 5241-5255, 2013
    12 - Mahmoud Elsabahy, Ritu Shrestha, Corrie Clark, Sara Taylor, Jeffrey Leonard, Karen L. Wooley, Multifunctional Hierarchically Assembled Nanostructures as Complex Stage-Wise Dual-Delivery Systems for Coincidental Yet Differential Trafficking of siRNA and Paclitaxel, Nano Letters,, Vol. 13, pp. 2172-2181, 2013
    13 - Shiyi Zhang, Jiong Zou, Mahmoud Elsabahy, Amolkumar Karwa, Ang Li, Dennis A. Moore, Richard B. Dorshow, Karen L. Wooley, Poly(ethylene oxide)-block-Polyphosphester-based Paclitaxel Conjugates as a Platform for Ultra-High Paclitaxel-Loaded Multifunctional Nanoparticles, Chemical Science, DOI: 10.1039/c3sc50252j, Vol. 4, pp. 2122-2126 , 2013
    14 - Fuwu Zhang, Mahmoud Elsabahy, Shiyi Zhang, Lily Yun Lin, Jiong Zou, Karen L. Wooley, Shell Crosslinked Knedel-like Nanoparticles for Delivery of Cisplatin: Effects of Crosslinking, Nanoscale, DOI: 10.1039/c3nr34320k, Vol. 5, pp. 3220-3225, 2013
    15 - Sandani Samarajeewa, Aida Ibricevic, Sean P. Gunsten, Ritu Shrestha, Mahmoud Elsabahy, Steven L. Brody, Karen L. Wooley, Degradable Cationic Shell Cross-Linked Knedel-like Nanoparticles: Synthesis, Degradation, Nucleic Acid Binding and In vitro Evaluation, Biomacromolecules,, Vol. 14, pp. 1018-1027, 2013
    16 - Mahmoud Elsabahy, Karen L. Wooley, Cytokines as Biomarkers of Nanoparticle Immunotoxicity, Chem. Soc. Rev., DOI: 10.1039/c3cs60064e, Vol. 42, pp. 5552-5576, 2013
    17 - Sandani Samarajeewa, Ritu Shrestha, Mahmoud Elsabahy, Amolkumar Karwa, Ang Li, Ryan P. Zentay, James G. Kostelc, Richard B. Dorshow, Karen L. Wooley, In vitro Efficacy of Paclitaxel-loaded Dual-responsive Shell Cross-Linked Polymer Nanoparticles Having Orthogonally Degradable Disulfide Cross-Linked Corona and Polyester Core Domains, Molecular Pharmaceutics,, Vol. 10, pp. 1092-1099, 2013
    18 - Mahmoud Elsabahy, Marianna Foldvari, Needle-free Gene Delivery Through the Skin: An Overview of Recent Strategies, Current Pharmaceutical Design, Vol. 19, No. 41, pp. 7301-7315, 2013
    19 - Ritu Shrestha , Mahmoud Elsabahy , Stephanie Florez-Malaver , Sandani Samarajeewa , Karen L. Wooley, Endosomal Escape and siRNA Delivery with Cationic Shell Crosslinked Knedel-Like Nanoparticles with Tunable Buffering Capacities, Biomaterials ,, Vol. 33, PP. 8557-8568 , 2012
    20 - Mahmoud Elsabahy, Karen L. Wooley, Strategies Toward Well-Defined Polymer Nanoparticles Inspired by Nature: Chemistry versus Versatility, Journal of Polymer Science, Part A: Polymer Chemistry, DOI: 10.1002/pola.25955, Vol.50, PP.1869–1880, 2012
    21 - Mahmoud Elsabahy and Karen L. Wooley, Design of Polymeric Nanoparticles for Biomedical Delivery Applications, Chem. Soc. Rev.,  DOI: 10.1039/c2cs15327k , Vol.41, PP. 2545–2561, 2012
    22 - Shiyi Zhang, Jiong Zou, Fuwu Zhang, Mahmoud Elsabahy, Simcha E. Felder, Jiahua Zhu, Darrin J. Pochan, Karen L. Wooley, Rapid and Versatile Construction of Diverse and Functional Nanostructures Derived from a Polyphosphoester-based Biomimetic Block Copolymer System, J. Am. Chem. Soc.,, Vol. 134, pp. 18467-18474, 2012
    23 - Ritu Shrestha, Mahmoud Elsabahy, Hannah Luehmann, Sandani Samarajeewa, Stephanie Florez-Malaver, Nam S. Lee, Michael J. Welch, Yongjian Liu, Karen L. Wooley, Hierarchically Assembled Theranostic Nanostructures for siRNA Delivery and Imaging Applications, J. Am. Chem. Soc.,, Vol. 134, pp. 17362-17365, 2012
    24 - Arnaud E. Felber, Bastien Castagner, Mahmoud Elsabahy, Glen F. Deleavey, Masad J. Damha, Jean-Christophe Leroux, siRNA Nanocarriers Based on Methacrylic Acid Copolymers, Journal of Controlled Release, doi:10.1016/j.jconrel.2010.12.012 , Elsevier, Vol. 152, pp. 159-167 , 2011
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    25 - Mahmoud Elsabahy, Adil Nazarali, Marianna Foldvari, Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions, Current Drug Delivery, Vol. 8, No. 3, pp. 235-244, 2011
    26 - Hui Gao, Mahmoud Elsabahy, Elisabeth V. Giger, Jianbiao Ma, Robert E. Prud'homme, Jean-Christophe Leroux, Self Assembling Properties of Aminated Poly(glycerol methacrylate)s, Journal of Controlled Release, doi:10.1016/j.jconrel.2011.08.050, Vol. 152, pp. e142-e143, 2011
    27 - McDonald Donkuru, Ildiko Badea, Shawn Wettig, Ronald Verrall, Mahmoud Elsabahy, Marianna Foldvari, Advancing Nonviral Gene Delivery: Lipid- and Surfactant-Based Nanoparticle Design Strategies, Nanomedicine, vol. 5, No. 7, pp. 1103-1127, 2010
    28 - Hui Gao, Mahmoud Elsabahy, Elisabeth V. Giger, Dekun Li, Robert E. Prud’homme, Jean-Christophe Leroux, Aminated Linear and Star-Shape Poly(glycerol methacrylate)s: Synthesis and Self-Assembling Properties, Biomacromolecules, vol. 11, No. 4, pp. 889-895 , 2010
    29 - Mahmoud Elsabahy, Nada Wazen, Núria Bayó-Puxan, Glen Deleavey, Marc Servant, Masad J. Damha, Jean-Christophe Leroux, Delivery of Nucleic Acids Through the Controlled Disassembly of Multifunctional Nanocomplexes, Advanced Functional Materials, DOI: 10.1002/adfm.200901139, Vol. 19, pp. 3862 - 3867, 2009
    30 - Marie-Hélène Dufresne, Mahmoud Elsabahy, Jean-Christophe Leroux, Characterization of Polyion Complex Micelles Designed to Address the Challenges of Oligonucleotide Delivery, Pharmaceutical Research, DOI: 10.1007/s11095-008-9591-6, vol. 25, No. 9, pp. 2083-2093, 2008
    31 - Mahmoud Elsabahy, Mingzhen Zhang, Shao-Ming Gan, Karen C. Waldron, Jean-Christophe Leroux, Synthesis and Enzymatic Stability of PEGylated Oligonucleotide Duplexes and their Self-Assemblies with Polyamidoamine Dendrimers, Soft Matter, DOI: 10.1039/b714221h, vol. 4, pp. 294-302, 2008
    32 - Mahmoud Elsabahy, Marie-Ève Perron, Nicolas Bertrand, Ga-er Yu, Jean-Christophe Leroux, Solubilization of Docetaxel in Poly(ethylene oxide)-block-poly(butylene/styrene oxide) Micelles, Biomacromolecules, vol. 8, No. 7, pp. 2250-2257, 2007

    Supervisions :

    1- Heba Ahmed Fathy, Development and Characterization of Nanostructured Lipid Carriers of Simvastatin, M. Sc, 25 February 2019
    Number of courses0 course