Background: Nausea and vomiting during pregnancy (NVP), is one of the most common complaints of pregnant women. Fetus’s gender is one that stimulates these complaints. Aim: This study aimed to assess the relationship between fetal sexand pattern of nausea, vomiting and cholasma among pregnant women. Methods: Descriptive research design. Sample size included 400 pregnant women in their third trimester, that divided into four groups (primi- gravida with female fetus, primi- gravida with male fetus, multi- gravida with female fetus and multi- gravida with male fetus), each group haveone hundred women, The study was conducted at antenatal outpatient clinic, Woman’s Health Hospital, Assiut University and Qlta Maternal and Child Health Care center, Assiut, Egypt. Data was collected by using interview questionnaire. Results: This study showed there was relationship between gender of the current pregnancy , pattern, onset, time, frequency, end date of nausea, vomiting and cholasma (p-value 0.001, 0.005, 0.001, 0.002, 0.003 and 0.003 respectively). Conclusion: This study revealed that NVP and cholasma are more likely to occur among female fetus than male. Recommendations: Increase mother's knowledge about the effect of pregnancy hormones related changes on thier health through health education program.