Psycho-educational program which enhanced health behaviors, increased coping skills, give information about what substance abuse is, and its complications on drug addict patients physical and mental health. Aim of the study: Evaluate the effect of psycho-educational program on depression among drug addict patients. Design: QuasiExperimental pretest posttest controlled design was used. Subjects and method: The studied sample consisted of 100 drug addict patients, 50 were study group & 50 were control group. Tools: Personal data, pattern of drug addiction questionnaire, and Beck Depression Inventory (BDI). Results: pre psycho-educational program, the majority of drug addict patients had severe levels of depression while, post program, the drug addict patients (study group) had less levels of depression than control group who didn't received psycho-educational program. Conclusion: Psycho-educational program had positive effects on levels of depression among study group than control group. Recommendations: Psycho-educational program should be part of the treatment strategies among drug addict patients and their families.