Babesia and Theileria are intraerythrocytic parasites which are capable of infecting a wide range of vertebrates causing huge economic losses. Histopathological and hematological changes during Babesia and Theileria inoculation in rat they were reported. Objective of the study is to determine the presence of Babesia & Theileria infected Camelus dromedarius at Assiut locality, Upper Egypt and their effects on hematological and tissues (liver, lung and kidney) of rat by injection in the blood. Blood samples were collected from Camelus dromedarius from different localities of Slaughter houses at Assiut city, Egypt (Dairout, Beni ady and Elethamna). Thick and thin blood smears were made for morphological examination of some protozoan blood parasites with electron microscopic studies. Out of (195) one hundred and ninety five Camelus dromedarius were examined and only twelve (6.1 %) were infected with Th. assiutis (n. sp.) and fifty one were found to be infected (26.1 %) with B. Cameli (n. sp.). For the first time the parasites were infected camels at Assiut. These parasites were injected in the blood of rat and the changes occurred on the organs were seen. Also Hemoglobin concentration, WBCs, RBCs, hematocrite, MCV, MCH and MCHC were measured for detection the hematological effects of these parasites. This study has reported for the first time the presence of Th. assiutis (n. sp.) & B. Cameli (n. sp.). in Camelus dromedarius and the results can lead to the prevention of babesiosis and theileriosis in the region to increase the livestock output.