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Toxicity and speciation of inorganic arsenics and their adverse effects on in vivo endpoints and oxidative stress in the marine medaka Oryzias melastigma

Research Authors
Eunjin Byeon, Haksoo Jeong, Min-Sub Kim, Seong Chan Yun, Jin-Sol Lee, Min-Chul Lee, Jin-Hyoung Kim, Alaa El-Din Hamid Sayed, Jun Bo, Hyung Sik Kim, Chulho Yoon, Atsushi Hagiwara, Yoshitaka Sakakura, Jae-Seong Lee
Research Abstract

Here, we investigate the effects of acute and chronic exposure to arsenate (AsV) and arsenite (AsIII) in the marine medaka Oryzias melastigmaIn vivo effects, biotransformation, and oxidative stress were studied in marine medaka exposed to the two inorganic arsenics for 4 or 28 days. An investigation of embryonic development revealed no effect on in vivo parameters, but the hatching rate increased in the group exposed to AsIII. Exposure to AsIII also caused the greatest accumulation of arsenic in medaka. For acute exposure, the ratio of AsV to AsIII was higher than that of chronic exposure, indicating that bioaccumulation of inorganic arsenic can induce oxidative stress. The largest increase in oxidative stress was observed following acute exposure to AsIII, but no significant degree of oxidative stress was induced by chronic exposure. During acute exposure to AsV, the increase in the enzymatic activity of …

Research Date
Research Department
Research Journal
Journal of Hazardous Materials
Research Member
Research Year
2024