Cluster and berry thinning are management techniques that adjust over-crop and provide a method for improving the quality. Furthermore, lately, a lot of attention is focused on minimizing the heavy amounts of mineral fertilizers by applying organic and bio-fertilizers such as vermicompost and humic acid. Therefore, these treatments were applied to increase the productivity and quality of Ruby Seedless table grape. To achieve this aim of this study, this study was conducted during two successive seasons of 2022 and 2023 on Ruby Seedless grape cultivar which was cultivated at the orchard of Pomology Department, Faculty of Agriculture, Assiut University. Six treatments were carried out control, humic acid at 2%/vine, humic acid to the soil at 5g/vine, vermicompost extract at 3.3ml/L, vermicompost extract at 5ml/L, cluster thinning by Removing the second cluster. Yield components, vegetative properties, berry attributes in addition to quality of grape berries were measured. The results revealed that all of the treatments were effective in improving both productivity and berry quality of the Ruby Seedless grape cultivar. In addition, spraying with vermicompost extract could be recommended as the best treatment.