combination and patients may require intensive care unit (ICU) treatment. Therefore, it seems necessary to identify prognostic clinical parameters and risk factors at the time of ICU admission. Aim of the study: To estimate the frequency of mortality and cirrhosis morbidity among patients with end stage liver disease (ESLD) admitted to the ICU and to evaluate the relation between demographic, clinical and laboratory data (potential risk factors) of those patients and mortality.Methods:120 patients with ESLD were enrolled [102 males (85%) and 18 females (15%)].History,clinical examination,full investigations and classification of patients according to Child-Turcotte-Pugh (CTP) and Model for end stage liver disease(MELD)score were done. Results: Regarding clinical presentation, hepatic encephalopathy (HE) was found in 87.5%, jaundice (60%), hematemesis (41.7%), hepatorenal syndrome (HRS)( 35.8%) and spontaneous bacterial peritonitis (SBP)(20.8%). Mortality rate was 57.5%; the main causes of death were HRS (40.8%), HE (21.7), aspiration pneumonia (10%), septic shock (2.5%) and irreversible shock in only 1.7%. There was a significant relation between mortality and old age, CTP and MELD scores and a longer stay at the ICU. Increased white blood cell count, increased hemoglobin and decreased prothrombin concentration and raised creatinine were independent risk factors of mortality in ESLD patients in the ICU. Mortality rates were higher(86.2%) with 5-6 risk factors and (21.7%) with 1-2 risk factor(s).Conclusions: Mortality rate in ESLD patients admitted to ICU was 57.5% and the most common cause of death was HRS. CTP, MELD score, HE, HRS and jaundice were significant predictors of mortality in ESLD patients. Mortality increased with increased number of risk factors. Creatinine level, white blood cell count, hemoglobin and prothrombin concentration were independent risk factors of mortality in ESLD patients