Background and aim: The prognostic role of neutrophil to lymphocyte ratio
(NLR) has been shown in many solid tumors included in a recent meta-analysis of one hundred studies. We aimed to evaluate the prognostic value
of neutrophil to lymphocyte ratio in treatment outcomes; response and survival of patients with different stages of rectal cancers. Patients and methods:
All patients with pathologically confirmed cancer rectum presented to our
department during the period from January 2012 to the end of 2014 were included in this retrospective study, these recruited patients were evaluated
through their files to determine different objectives of our study. Results: The
median overall survival was 31 ± 4.676 months while disease free survival was
40 ± 2.346 for the whole study group; neutrophil to lymphocyte ratio was negatively correlated with overall survival with r = −0.743, P < 0.001, also with
disease free survival with r = −0.717, P < 0.0001. Neutrophil to lymphocyte
ratio was positively correlated with the number of positive lymph nodes dissected to total number of lymph nodes dissected ratio with r = +0.254, P =
0.028. Roc curve was used to find the accurate cut point of NLR for these patients and was found to be of 4.5. Conclusion: Elevated pre-treatment NLR is
an independent predictor of shorter survival in patients with rectal cancer.
This parameter is a simple, easily accessible laboratory test for identifying patients with poorer prognosis.