Osteoprotegerin, Soluble Receptor Activator Nuclear Factor-κB Ligand, Nuclear Factor Kappa B and Intestinal Trefoil Factor 3 Are Promising Biomarkers In Diagnosis And Follow- up Inflammatory Bowel Disease Patients

Faculty of Medicine

Assiut University

Osteoprotegerin, Soluble Receptor Activator Nuclear Factor-κB Ligand, Nuclear Factor Kappa B and Intestinal Trefoil Factor 3 Are Promising Biomarkers In Diagnosis And Follow- up Inflammatory Bowel Disease Patients

Research Authors
Ragaa HM Salama , Mohammed A Medhat, Shimaa A Elghazally , Nesma G Farag, Aya A El Sanory ,Mohamed O Herdan, Tasneem A El Sanory , Amira A kamel .
Research Date
Research Department
Department of Biochemistry
Research Journal
The Egyptian Journal of Hospital Medicine
Research Member
Nesma Gamal Abd Elnaem Farag
Research Abstract

The hypothesis of this study based on OPG is the decoy receptor of sRANKL which bind with its receptor RANK and activate NF-κB. This pathway may involve in the pathogenesis of IBD and any interference with pathway may affect the progress of the disease. The role of RANK/RANKL inhibition as an immunomodulatory.  While TFF3 is a good marker indicating healing of mucosa   and a state of remission.