T-lymphocytes expression of Toll-like receptors 2 and 4 in acute myeloid leukemia patients with invasive fungal infections

South Egypt Cancer Institute

Assiut University

T-lymphocytes expression of Toll-like receptors 2 and 4 in acute myeloid leukemia patients with invasive fungal infections

Research Authors
Muhamad R Abdel Hammed, Sherein G Elgendy, Mohamed A El-Mokhtar, Douaa Sayed, Samar M Mansour, Abeer M Darwish
Research Member
Samar Muhammad mansour
Abeer Mostafa Mostafa Darwish
Research Department
Department of Clinical Pathology
Research Date
Research Year
2022
Research Journal
Mediterranean Journal of Hematology and Infectious Diseases
Research Abstract

Invasive fungal infections (IFIs) are important cause of mortality in acute myeloid leukemia (AML) patients on treatment with intensive induction chemotherapy. Toll-like receptors, mainly Toll-like receptors 2 and 4 (TLR2 and TLR4), play a considerable role in the host defense against microorganisms. The involvement of TLR signaling in modulation of innate immune response is extensively discussed, but the TLR expressions profiling on adaptive immune cells are not specified. Also, the expressions of TLRs and their association with the occurrence of IFIs in patients with AML are not studied. So, the novel aim of this study was to investigate the associations between the T-lymphocyte expression of TLR2 and TLR4 and the occurrence of IFIs in AML patients treated with intensive induction chemotherapy.