Background: The COVID-19 is spread by human-to-human through droplets, fecooral, and direct contact with patients during 2-14 days. Therefore, applying preventive

measures to control COVID- 19 infection is the most critical intervention. Aim: To evaluate

the effect of online educational program on COVID19 patients' knowledge, self-monitoring,

and self-care. Subjects and methods: Design: A quasi-experimental (Pre & Post-test) study

was conducted on 112 COVID-19 patients; online pretest during their staying at isolation

areas and online posttest one month later after discharge from isolation areas. Setting:

Isolation area at Assiut university dorms, in addition to isolation areas in all Assiut university

hospitals which include Main University Hospital, Urology University Hospital and AlRajhi University Hospital , moreover online posttest from patients' homes .Tools: Three tools

were used which conducted by on line way, on-line self-reported COVID -19 knowledge

questionnaire, daily self-monitoring form and self-care questionnaire. Results: there was a

significant statistical difference between pre, post online education regarding patients’ selfcare toward COVID-19 in physical, mental, professional, and social well-being domains with

p.value (0.0001, 0.004, 0.0001,and 0.0001) respectively. Also, there was a positive

correlation between patients' knowledge and patient self-care post online education.

Conclusion: Online distance learning has a great effect on COVID19 patients' knowledge,

self-monitoring, and self-care in isolation units. Recommendations: Providing a printed

copy of the educational brochure in outpatient clinics for patients and their relatives