Background: Sickle Cell Disease (SCD) is a chronic disorder that has an impact on a patient’s quality of life. A structured education booklet has the potential to affect self-efficacy, self-care practices and subsequently better quality of life. Aim: To investigate the effect of structured education booklet on self-efficacy, self-care practices and health related quality of life in adult patients with sickle cell disease.Design: Pre experimental one group (pretest-posttest) design. Top of FormBottom of FormSetting: Inpatient and outpatient clinic, Clinical Hematology Unit, Department of Internal Medicine Assiut University Hospital. Study subjects: Purposive sample of forty adult patients with sickle cell disease of both sexes were included in the study and followed up for 3 months. Data collection tools: (I) structured interviewing questionnaire, (II)Sickle Cell Self-Efficacy Scale, (III) Self-care practices assessment sheet (a-Jeanerette Self-care Assessment Tool, b-The 24-item Appraisal of Self-care Agency Scale) and (IV)Adult Sickle Cell Quality of Life Measurement Information System. Results: The mean score of self-efficacy (14.25±2.78Vs.30.22±3.37), self-care practices measured as self-care actions (20.2±1.4Vs. 27.55±1.65), perceived self-care ability (65.9±4.1 Vs. 97.25±11.3), and health-related quality of life improved significantly when compared to the pre-structured education (p < 0.001**). Conclusion: Structured education booklet improved patient’s self-efficacy, self-care practices, hence improving QOL in SCD patients. Recommendation: The study findings underscore the significance of implementing structured education booklet as an integral component of management of individuals with sickle cell disease as a means of enhancing self-efficacy, care practices and health-related quality of life.