A health information system (HIS) is a comprehensive, integrated and specialized system that manages both administrative and clinical aspects of hospitals and healthcare information facilities. Aim: Proposed a job description model for nurses who use hospital information systems. Study subjects: All available ICU nurses at Al-Rajhy Hospital who are using HIS (no = 26). Study tools: Three tools were used, namely, personal data sheet, diary and observational performance checklist. Result: The majority of the nurses in the study recorded vital signs, assessed the patient’s condition, made beds, and documented patient data electronically. Conclusion: The majority of the subject is responsible for all aspects of attendance and punctuality, appearance, work habits, staff relations and communications with patients, nursing care plan activities, material planning, safety measures and patient safety, documentation electronically, coordination, and staying technically up to date. Recommendation: A job description should be added to the HIS user manual and distributed widely to support the nursing staff. Continuing training workshops for new HIS users should be established to improve their computer skills. Keywords: Health information system, Job description, Nursing informatics.