Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
51 Design, synthesis, and antiproliferative properties of new 1, 2, 3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors 2023
52 Synthesis, biological evaluation and molecular docking study of some new 4-aminosalicylic acid derivatives as anti-inflammatory and antimycobacterial agents 2023
53 Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl) Quinolin-2(1H)-Ones as Multi-Target Inhibitors 2023
54 Design, synthesis and antiproliferative evaluation of lipidated 1, 3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors‏ 2023
55 Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies 2022
56 Crystal structure and Hirshfeld surface analysis of 5-acetyl-3-amino-6-methyl- N -phenyl-4-[( E )-2-phenylethenyl]thieno[2,3- b ]pyridine-2-carboxamide 2022
57 New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition 2022
58 New 1, 3, 4‐oxadiazoles linked with the 1, 2, 3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase 2022
59 The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45 −/− immunodeficient B cells 2022
60 New 1,3,4-Oxadiazole-Chalcone/Benzimidazole Hybrids as Potent Anti-proliferative Agents 2022