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Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
171 (Z)-3Hydrazinylidene-1-phenylindolin-2-one. 2010
172 Pharmacophoric Model Building for
Antitubercular Activity of the Individual Schiff
Bases of Small Combinatorial Library
2010
173 Schiff Bases of Indoline-2,3-dione (Isatin) Derivatives and Nalidixic Acid Carbohydrazide, Synthesis, Antitubercular Activity and Pharmacophoric Model Building. 2010
174 Synthesis of disulfated peptides corresponding to the
N-terminus of chemokines receptors CXCR6 (CXCR61−20) and DARC (DARC8−42) using a
sulfate protecting group strategy
2010
175 Pharmacophoric Model Building for
Antitubercular Activity of the Individual Schiff
Bases of Small Combinatorial Library
2010
176 Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and Chemoprotective Enzymes in Mice. 2010
177 Specific brain delivery of pyridyl chloroethylurea derivatives as potential antitumor agents: synthesis, evaluation and molecular modeling study

2010
178 Brain-Specific Delivery of Naproxen Using Different Carrier
Systems
2010
179 New Sensitive HPLC Method for Evaluation of the Pharmacokinetics of New Amantadine Prodrugs as Hepatic Delivery Systems to Enhance its Activity against HCV 2010
180 Design and Synthesis of a Combinatorial Library of Indoline-2,3-dione Schiff bases with Potential Anti-tubercular Activity. 2010