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Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
161 Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids 2011
162 Decoration of polymeric micelles with cancer-specific peptide ligands for active targeting of paclitaxel 2011
163 Novel Microwell-based Spectrophotometric Assay for Determination of Atorvastatin Calcium in its Pharmaceutical Formulations 2011
164 Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of a Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential Antimycobacterial Activity 2011
165 Synthesis, Biological Evaluation and Molecular Modeling Study of Substituted 1,2,4-Triazole-3-Acetic Acid Derivatives 2011
166 Cell Screening Assay for Identifying Inhibitors of Eosinophil Proliferation 2011
167 Schiff Bases of Indoline-2,3-dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase. 2011
168 Synthesis of disulfated peptides corresponding to the
N-terminus of chemokines receptors CXCR6 (CXCR61−20) and DARC (DARC8−42) using a
sulfate protecting group strategy
2010
169 Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and Chemoprotective Enzymes in Mice. 2010
170 Specific brain delivery of pyridyl chloroethylurea derivatives as potential antitumor agents: synthesis, evaluation and molecular modeling study

2010