Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
151 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
152 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
153 Novel Pyrrol-2(3H)-ones and Pyridazin-3(2H)-ones Carrying Quinoline Scaffold as Anti-Proliferative Tubulin Polymerization Inhibitors 2018
154 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
155 Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils 2018
156 Synthesis, Anticancer Activity and Molecular Modeling Studies of 1,2,4-Triazole Derivatives as EGFR Inhibitors 2018
157 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
158 Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils 2018
159 Design, Synthesis, Mechanistic and Histopathological Studies of Small-Molecules of Novel Indole-2-Carboxamides and Pyrazino[1,2-a]indol-1(2H)-ones as Potential Anticancer Agents Effecting the Reactive Oxygen Species Production 2018
160 Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils 2018