Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
181 Design and Synthesis of Novel 5-Aminosalicylate (5-ASA)–4-Thiazolinone Hybrid Derivatives with Promising Antiproliferative Activity 2016
182 Design and Synthesis of Novel 5-Aminosalicylate (5-ASA)–4-Thiazolinone Hybrid Derivatives with Promising Antiproliferative Activity 2016
183 Synthesis Of New 4-Aminosalicylates-, Triazole- and Hydrazide-Based Conjugates With Potential Anti-Tubercular Activity. 2016
184 Synthesis Of New 4-Aminosalicylates-, Triazole- and Hydrazide-Based Conjugates With Potential Anti-Tubercular Activity. 2016
185 Design and Synthesis of Ligands and Antagonists of Siglecs as Immune Response Modifiers 2016
186 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
187 Synthesis and Preliminary Biological Screening of 6-Aminopyrazolo[3,4-b]pyridine Derivatives 2016
188 Synthesis and investigation of antihypertensive activity using anaesthetized normotensive nonhuman primates of some 2-aryl-4-(substituted) pyrimido[1,2-a] benzimidazoles 2015
189 A-ring Substituted 17 β-Arylsulfonamides of 17β-Aminoestra-1,3,5(10)-trien-3-ol as Highly Potent Reversible Inhibitors of Steroid Sulfatase 2015
190 Synthesis and biological evaluation of cystobactamid 507: A bacterial topoisomerase inhibitor from Cystobacter sp. 2015