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Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
341 Tetrahydro-2H-1,3,5-thiadiazin-5-(4-pyridylcarboxamide)-2-thione Derivatives as prodrugs for Isoniazid, Synthesis, Investigations and In Vitro Antituberculous Activity. 1999
342 Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis, Characterization and in vitro Stability. 1999
343 Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis, Characterization and in vitro Stability. 1999
344 Cyclic amide derivatives as potential prodrugs: N-hydroxymethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. 1999
345 Metronidazole Twin Ester Prodrugs II : Non Identical Twin Esters of Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline Derivatives. 1998
346 Cyclic amide derivatives as potential prodrugs: N-hydroxmethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. 1998
347 Effects of Paeoniflorin Derivatives on the Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship. 1998
348 Cyclic amide derivatives as potential prodrugs: N-hydroxmethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. 1998
349 Effects of Paeoniflorin Derivatives on the Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship. 1998
350 A Structurally Simplified Analogue of the Antibiotic Heptelidic Acid With a Five Membered Carbocyclic Ring. 1998