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Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
351 Metronidazle Twin Esters Prodrugs II : Non Identical Twin Esters of Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline Derivatives. 1998
352 Effects of Paeoniflorin Derivatives on the Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship. 1998
353 Cyclic amide derivatives as potential prodrugs: N-hydroxmethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. 1998
354 Esters Twin Drugs of Metronidazole : Synthesis, Physicochemical properties, Kinetic studies and Antigardial activity. 1998
355 Paracetamol (Acetaminophen) Esters of Some Non-steroidal Anti-inflammatory Carboxylic acids Drugs as Mutual Prodrugs with Improved Therapeutic Index. 1998
356 A Structurally Simplified Analogue of the Antibiotic Heptelidic Acid With a Five Membered Carbocyclic Ring. 1998
357 Esters Twin Drugs of Metronidazole : Synthesis, Physicochemical properties, Kinetic studies and Antigardial activity. 1998
358 Paracetamol (Acetaminophen) Esters of Some Non-steroidal Anti-inflammatory Carboxylic acids Drugs as Mutual Prodrugs with Improved Therapeutic Index. 1998
359 Polymeric prodrug:  and -poly (N-hydroxy-ethyl) aspartamide as carrier for controlling the release of theophylline. 1998
360 Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by Incubation of Paeoniflorin and Sulfhydryl Compounds With Lactobacillus Brevis. 1998