Development of Oral Formulation of Lepidium Seeds Significantly Decreases the High Blood Glucose Levels in Diabetic Rats; In Vitro Formulation and In Vivo Antidiabetic Performance.

Faculty of Pharmacy

Assiut University

Development of Oral Formulation of Lepidium Seeds Significantly Decreases the High Blood Glucose Levels in Diabetic Rats; In Vitro Formulation and In Vivo Antidiabetic Performance.

Research Authors
• Basmah N. Aldosari, Ahmed A. H. Abdellatif, Alanood Sunhat Almurshedi, Iman Mohammed Alfagih, Bushra Tawfeeq AlQuadeib, Asmaa Youssef A. Abbas, Yasser A. Hassan, Ahmed Abdelfattah, Hesham M. Tawfeek
Research Date
Research Department
Department of Industrial Pharmacy
Research Journal
Drug development and industrial Pharmacy
Research Publisher
Taylor and Francis
Research Vol
50
Research Website
https://www.tandfonline.com/doi/abs/10.1080/03639045.2023.2300649
Research Year
2024
Research Member
Hesham Mohamed Tawfeek Hassan
Ahmed Abdelfattah Mohamed Ahmed
Research_Pages
112-123
Research Abstract

Background

Lepidium sativum, Garden Cress (GC), seeds have a lot of natural molecules with a pronounced activity against different disorders. It was reported that GC seeds have the ability to lower the blood glucose level.

Aim

The aim of this work was to formulate GC seeds into oral tablets containing a fixed dose of the grounded seeds. Furthermore, the anti-diabetic performance of the prepared tablets was studied in the streptozotocin rats’ model in comparison with positive control metformin.

Methods

Micrometrics of GC grounded seeds with different excipients were investigated. Then, GC tablets were prepared via direct compression technique. GC tablets were characterized for their uniformity of dosage unit, friability, hardness, disintegration time, and in vitro release. The antidiabetic effect was studied in rats for a period of 28 days. Glycosylated hemoglobin, liver performance, and lipid levels include total cholesterol (TC), triglycerides (TGs), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also estimated. In addition, histopathological study of liver and pancreas was also performed.

Results

Prosolv®EasyTab produced tablets with higher hardness, lower disintegration time, and fast release. GC tablets significantly lower the elevated blood glucose level. In addition, they have antihyperlipidemic activity, hepatocellular protective role and restore the histology of the liver and pancreas.

Conclusion

GC tablets could be a promising alternative formulation to control the high blood glucose level in diabetic rats rather than chemically derivatized drugs.