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Synthesis and Reactions of New Hydrazinyl-2,7-naphthyridines and Pyrimidothieno[2,3-c][2,7]naphthyridine Morpholine Derivatives

Research Authors
A. M. K. El-Dean, A. A. Geies, R. Hassanien, F. K. Abdel-Wadood, and E. E. Abd El-Naeem
Research Abstract

The reaction of 7-methyl-1-(morpholin-4-yl)-3-sulfanylidene-2,3,5,6,7,8-hexahydro-2,7-naph thyridine-
4-carbonitrile with hydrazine hydrate gave 1-hydrazinyl-7-methyl-3-sulfanylidene-2,3,5,6,7,8-hexahydro-
2,7-naphthyridine-4-carbonitrile which was used as a key intermediate for the synthesis of new fused naphthyridine-
based heterocyclic systems. The condensation of 1-amino-7-methyl-5-(morpholin-4-yl)-6,7,8,9-
tetra hydrothieno[2,3-c][2,7]naphthyridine-2-carbonitrile with different reagents afforded fused tetra- and
pentacyclic systems. The structure of the newly synthesized compounds was confirmed by elemental analysis
and spectral techniques.

Research Date
Research Department
Research File
Research Journal
Russian Journal of Organic Chemistry
Research Publisher
Pleiades Publishing, Ltd.
Research Vol
58
Research Website
DOI: 10.1134/S1070428022090147
Research Year
1922
Research Pages
1287–1296