Synthesis, Reactions, and Spectral Characterization of New Fused Pyrazolothienopyridine and Pyrazolopyrrolopyridine Systems | Faculty of Science Skip to main content

Synthesis, Reactions, and Spectral Characterization of New Fused
Pyrazolothienopyridine and Pyrazolopyrrolopyridine Systems

Research Authors
A. A. Geies, M. I. Abdel Moneam, A. M. Kamal El-Dean, R. M. Zaki, E. E. Abd El-Naeem
Research Abstract

4-Oxo-1-phenyl-4,7-dihydropyrazolo[3,4-b]pyridine-5-carbonitrile compound (4) was prepared by the
reaction of 5-amino-3-methyl-1-phenyl pyrazole (1) with ethyl 2-cyano-3-ethoxyacrylate followed by
cyclization using diphenyl ether. The pyrazolopyridinone compound 4 was converted to the
chloropyrazolopyridine 5 by the reaction with phosphorus oxychloride. Compound 5 was used as a starting
material to synthesize 3-amino-4-substituted pyrazolothienopyridine derivatives 10a–f and ethyl-3-
aminopyrazolopyrrolopyridine-2-carboxylate 21, which were used as a versatile precursors for synthesis
of poly-fused heterocyclic compounds.

Research Department
Research Journal
J. Heterocyclic Chem.
Research Publisher
NULL
Research Rank
1
Research Vol
vol. 54
Research Website
NULL
Research Year
2017
Research Pages
pp. 2012