Important Announcement for Pharm D Students – Allocation of Students into Practical Lessons for the Course "Applied and Forensic Pharmacognosy" (First Semester – Academic Year 2025/2026)

The allocation of students into the practical Lessons will be as follows:

  • First Period: 8:00 – 10:00 a.m.
    • From student ID 2210053 to the last number
    • From student Shereen Ahmed Ahmed Fayyad to the last name
  • Second Period: 10:00 a.m. – 12:00 p.m.
    • From student ID 2210004 to 2211052
    • From student Ahmed Gamal Abdelwahab to student Shorouk Abdo Ibrahim

إعلان هام لطلاب الفارم دي – توزيع الطلاب داخل سكاشكن العملى لمقرر عقاقير تطبيقي وشرعي الفصل الدراسي الأول للعام الجامعى 2025/2026

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إعلانات الطلاب

Final schedule of lectures and practical lessons according to the credit hour system for the Bachelor of Pharmacy (Clinical Pharmacy) for the first semester of the academic year 2025/2026

 

 

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إعلانات الطلاب

The Faculty of Pharmacy concludes its preparations for welcoming the new academic year 2025/2026

تحت رعاية معالى السيد الأستاذ الدكتور / أحمد المنشاوى - رئيس الجامعة ، والسيد الأستاذ الدكتور / أحمد محمد عبدالمولى - نائب رئيس الجامعة لشئون التعليم والطلاب ، قامت السيدة الأستاذ الدكتور / جيهان نبيل فتيح - عميد الكلية ، يرافقها السيد الأستاذ الدكتور / حسن رفعت حسن -وكيل الكلية لشئون التعليم والطلاب ، والسيدة الأستاذ الدكتور/ دينا فتح الله محمد _ وكيل الكلية لشئون الدراسات العليا والبحوث، بعمل جولة تفقدية للمدرجات والمعامل بمختلف الأقسام حيث إطمئنت سيادتها على توفير كافة إحتياجات وإمكانيات العملية التعليمية وعناصر الجودة والإنتهاء من كافة أعمال الصيانة وإعلان الجداول لكل الفرق الدراسية قبل إنطلاق العام الجامعى الجديد 2025/2026 م بما يضمن حسن سير العملية التعليمية على الوجه الأكمل .
تم ذلك يوم السبت الموافق ٢٠٢٥/٩/٢٠

كلية الصيدلة تنهى إستعداداتها لإستقبال العام الجامعى الجديد 2026/2025 م

كلية الصيدلة تنهى إستعداداتها لإستقبال العام الجامعى الجديد 2026/2025 م

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خبر عام

Design, synthesis, molecular modeling, and antiproliferative evaluation of new 2-oxoindolin-3-ylidene thiazole derivatives

Research Abstract

A series of novel 2-oxoindolin-3-ylidene thiazole derivatives were designed and synthesized, inspired by the pharmacophoric features of the VEGFR-2 inhibitor sunitinib. These compounds were evaluated for antiproliferative activity against a panel of sixty cancer cell lines at the US National Cancer Institute, identifying derivatives 4b, 4c, 4d, 4l, and 6c as the most potent, with mean growth inhibition percentages of 118.86%, 135.32%, 148.27%, 126.16%, and 78.46%, respectively. Further cytotoxicity assessments against the HepG2 cell line revealed IC50 values ranging from 3.13 to 30.54 μM. These compounds also demonstrated strong VEGFR-2 inhibition, with IC50 values of 0.113, 0.047, 1.549, 0.995, and 0.089 μM, respectively, compared to sunitinib's IC50 of 0.167 μM. Selectivity index analysis indicated high selectivity for HepG2 cells over THLE-2 normal cells (1.80–10.26), suggesting favourable safety profiles compared to sunitinib (1.15). Notably, compound 4c induced G0/G1 phase cell cycle arrest, promoted apoptosis, upregulated caspase-3 and -9 expression, and delayed wound closure by 60.74%. Molecular docking studies confirmed strong binding interactions within the VEGFR-2 active site, while in silico ADME and DFT analyses supported favourable pharmacokinetic properties and reactivity. These findings position compound 4c as a promising lead for the development of anticancer agents.

Research Authors
Aalaa F. El-Mokadem, Mohammed K. Abd El-Gaber, Pak Hei Chung, Siang-Boon Koh, Hoda Y. Hassan and Adel F. Youssef
Research Date
Research Department
Department of Medicinal Chemistry
Research Image
Research Journal
R S C Medicinal Chemistry
Research Member
Adel Fawzy Yousef Mohiel-Deen
Hoda Youssef Hassan Huosien
Mohamed Khalifa Abdelgaber Khalifa
Aalaa Fathy Bakr Ali
Research Publisher
The Royal Society of Chemistry
Research Vol
16
Research Website
https://doi.org/10.1039/d5md00332f
Research Year
2025

Final schedule for lectures and practical lessons, Clinical Pharmacy Program, Faculty of Pharmacy and Pharmaceutical Research, National University, for the first semester of the academic year 2025/2026

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Link to enter the lecture schedule

 

 

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إعلانات الطلاب

Lists of Students for the Elective Courses of the Pharm-D Bachelor’s Program Fourth and Fifth Year for the First Semester of the Academic Year 2025/2026

 

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below for the list of fourth-year students:

 

 

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 below for the list of fifth-year students:

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إعلانات الطلاب

Lists of Students for the Elective Courses of the Pharm-D Bachelor’s Program (Clinical Pharmacy, Semesters 7 and 9) for The First Semester of the Academic Year 2025/2026

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 below for the list of students in Semester 7:

 

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 below for the list of students in Semester 9:

 

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إعلانات الطلاب

Announcement for Postgraduate Applicants for the Academic Year 2025/2026

إعـــــــلان للمتقدمين للدراسات العليا للعام الجامعي 2026/2025The Faculty of Pharmacy – Assiut University announces the acceptance of all applicants for the Diploma and Doctor of Pharmacy degrees for the academic year 2025/2026.
All applicants for the PhD and Master’s degrees are requested to proceed to the Postgraduate Studies Administration at the Faculty to complete the required procedures.
With best wishes for continued success and excellence.

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إعلانات الدراسات العليا
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