Thirty-two mature male rabbits were used in this study. They were divided into two groups: the control group (n= 8) and the experimental (n= 24) group; the experimental group was injected intraperitoneally with alloxan (180mg/ml/kg body weight). After 3 weeks, this group (diabetic rabbits) was subdivided into three subgroups of eight rabbits each. The first one was left as the untreated diabetic subgroup; rabbits in the second and third subgroups were treated daily for 7 days with ALA and NAC (100 mg/ml/kg body weight), respectively. At the end of the experiment, blood and kidney sections were processed for biochemical and histological studies.