Regulatory T-lymphocyte subsets in children with chronic immune thrombocytopenia after high-dose of dexamethasone

South Egypt Cancer Institute

Assiut University

Regulatory T-lymphocyte subsets in children with chronic immune thrombocytopenia after high-dose of dexamethasone

Research Authors
Khalid Ibrahim Elsayh, Khaled Saad, Naglaa Samy Osman, Khaled Hashim Mahmoud, Faisal A Ahmad, Shaimaa M Khalaf, Noha G Sayed, Zeinab Albadry M Zahran, Aliaa MA Ghandour, Amira A Elhoufey, Tamer Bedir, Asmaa Zahran
Research Member
Asmaa Mohamed Zahran Omar
Noha gaber sayed
Research Department
Department of Clinical Pathology
Research Date
Research Year
2022
Research Journal
Pediatric Research
Research Abstract

Immune thrombocytopenia (ITP) is an acquired autoimmune disease. This study’s objective was to estimate the variations in the population of CD4+CD25+High FoxP3+ cells (CD4+ regulatory T-lymphocytes; Tregs) in previously untreated children with chronic ITP managed in Assiut University Hospitals, as well as to evaluate the efficacy of high-dose dexamethasone (HD-DXM) in these patients.

Methods

In this study, we investigated the frequencies of T-lymphocyte subsets in 27 untreated children with chronic ITP.

Results

Prior to treatment, the percentages of CD4+CD25High cells and Tregs were significantly lower in the chronic ITP group compared to the control group (p = 0.018 and p < 0.0001, respectively). After treatment with HD-DXM, Tregs and platelets were significantly increased in these patients (p < 0.0001 for both).

Conclusions

Our results suggest that Tregs are deficient in children with