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Influence of intraoperative radiation therapy on locally advanced and recurrent colorectal tumors: A 16-year experience

Research Authors
Justin T. Brady a, Benjamin P. Crawshaw a, Barrington Murrell b, Eslam M.G. Dosokey a, Murad A. Jabir a, Scott R. Steele a, Sharon L. Stein a, Harry L. Reynolds Jr a, *
Research Member
Research Department
Research Year
2017
Research Journal
The American Journal of Surgery
Research Publisher
NULL
Research Vol
Vol. 213
Research Rank
1
Research_Pages
pp. 586 - 589
Research Website
NULL
Research Abstract

Background: Intraoperative radiation therapy (IORT) has been proposed as a tool to improve local control
in patients with locally advanced primary or recurrent colorectal cancer.
Methods: A retrospective review (1999e2015) of all patients undergoing IORT for locally advanced or
recurrent colorectal cancer at a single academic center was performed. Patient demographics, oncologic
staging, short-term and long-term outcomes were reviewed.
Results: There were 77 patients (mean age 63 ± 11 years) identified, of whom 19 had colon cancer, 57
had rectal cancer, and 2 had appendiceal cancers. R0 resection was performed in 53 patients (69%), R1 in
19 (25%) and R2 in 5 (6%). Ten (13%) patients had a local recurrence at 18 ± 14 months and 34 (44%) had a
distant recurrence at 18 ± 18 months. Mean survival was 47 ± 41 months.
Conclusion: IORT resulted in low local failure rates and should be considered for patients with locally
advanced or recurrent colorectal cancers.