Abstract: The effects of feeding Moringa Oleifera leaves meal (MOLM) as a nontraditional feed on performance and immune response were studied in broiler chicks raised on floor litter from 1 till 5 weeks of age. A total of 144 Cobb strain broiler chicks were distributed into 3 treatments (48 chicks/ treatment) with 4 replicates per treatment and 12 chicks per pen. Dietary MOLM levels of 0, 2, and 4% were supplemented to a basal ration (control) containing 22.4% crude protein and 3100 Kcal/kg metabolizable energy so that the three diets were isocaloric and isonitrogenous and met the requirements of broilers for all essential nutrients. Results indicated that at 4 weeks of age, body weight of birds fed the 2% MOLM was numerically higher than those of both the control and 4% MOLM. At 5 weeks of age, however, the body weight of birds offered the 4% dietary MOLM, was lowered (P<.05) by 3.6 and 2.4% as compared to the control and 2% MOLM, respectively. The overall means of feed conversion values of all treatments were comparable (1.9). However, at 5 week-old the 4% MOLM recorded lower FCR (2.7) than (P<.01) both control and 2% MOLM (2.3 and 2.4, respectively). Protein conversion ratio values indicated that the chicks received 2% MOLM were superior (2.36) to the control 0.0% and 4% MOLM fed groups (2.53 and 2.81%, respectively). Performance index (PI) and production number (PN) showed no differences among all treatments. Lymphoid organs weight as (%) of body weight showed that bursa % in the group received 2% MOLM recorded the highest (P<.01) weight in comparison to the control and 4% (.189% vs. .105 and .112%, respectively) in response to dietary supplementation. The percentage of abdominal fat was numerically lower in 2% MOLM fed group and coincided with a decreased (P<.01) level of ether extract % in body composition analyses. In conclusion, MOLM could be incorporated at 2% in broiler diets for improving carcass quality, immune response and protein conversion ratio.