Hypovitaminosis D among patients with hip fractures in a level-I Trauma Center - Upper Egypt

Faculty of Medicine

Assiut University

Hypovitaminosis D among patients with hip fractures in a level-I Trauma Center - Upper Egypt

Research Authors
Dalia G. Mahran 1, Osama Farouk 2, Hatem Said2, Mohammad Alaa2, Amr Atef2, Galal Z. Said2, Heba Rashed3, Azza Ez-Eldeen3
Research Department
Department of Public Health and Community Medicine
Research Journal
International Osteoporosis Foundation
Research Member
Dalia Galal Mahran mohamed
Research Rank
3
Research Year
2015
Research Abstract

Objectives: to determine the prevalence of hypovitaminosis D, its association with bone density and to evaluate related determinants among admitted patients to Trauma Unit in Assiut University Hospitals.

Materials and methods: A cross sectional study was carried out on patients with proximal femoral fractures aged 50 years and older admitted to Trauma Unit of Assiut University Hospitals, a level-I trauma center in Upper Egypt, from 1st January to end of December 2014. A randomized sample of 133 participants was included. Patients with polytrauma, major accidents and conditions known to affect bone density were excluded. Two well trained nurses filled a structured questionnaire by personal interview. Weight and height measurement, assessment of 25-hydroxy-vitamin D (25OHD) serum and bone mineral density measurement by DXA were done for all participants. A formal consent was taken from all participants prior to the study.

Results: Participants aged 50-99 years with mean 69 ± 11.3 years, 48.1% were males and 51.9% were females. 50.4% and 22.6% of them were housewives and farmers respectively. Osteoporosis (T score of neck fe-mur <-2.5) prevalence was 72.2%.

Prevalence of (25OHD) deficiency (<20 ng/ml) and inadequacy (between 20-30 ng/ml) were 60.9% and 15.8% respectively, and 23.3% were normal (> 30 ng/ml). Vitamin D level was positively correlated with T score of greater trochanter, neck femur, L4, L3 and L2 (r=0.23& p= 0.012, r= 0.28& p=0.001, r= 0.196& p=0.023, r= 0.18&p= 0.036 and r= 0.21 &p=0.02). Vitamin D deficiency was significantly associated with age and increase in BMI (p=0.04&0.012). Lack of milk and yoghurt intake had sig-nificant higher prevalence of vitamin D deficiency than others (p=0.02 and 0.01 respectively). No significant relation was found with sex or edu-cation level. Multiple regression analysis was done.

Conclusions: Prevalence of vitamin D deficiency is high among hip fracture patients and is associated with low BMD. Vitamin D supplementation is strongly recommended for prevention of hip fractures in those aged >50 years.