Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
131 Development of Near-Infrared Fluorescent Probes with Large Stokes Shifts for Non-Invasive Imaging of Tumor Hypoxia 2020
132 Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives 2020
133 Design, Synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors 2020
134 Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities 2019
135 Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives 2019
136 Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives 2019
137 Self-Assembled Tannic Acid Complexes for pH-Responsive Delivery of Antibiotics: Role of Drug-Carrier Interactions 2019
138 Aryl Azide-Sulfonamide Hybrids Induce Cellular Apoptosis: Synthesis and Preliminary Screening of Their Cytotoxicity in Human HCT116 and A549 Cancer Cell Lines 2019
139 Novel Quinoline Derivatives Carrying Nitrones/Oximes Nitric Oxide Donors: Design, Synthesis, Antiproliferative and Caspase-3 Activation Activities 2019
140 Thiohydantoin Derivatives Incorporating A Pyrazole Core: Design, Synthesis and Biological Evaluation as Dual Inhibitors of Topoisomerase-I and Cycloxygenase-2 with Anti-Cancer and Anti-Inflammatory Activities 2019