Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
141 Stereoselective trimethylsilylation of α- and β-galactopyranoses 2019
142 Novel Quinoline Derivatives Carrying Nitrones/Oximes Nitric Oxide Donors: Design, Synthesis, Antiproliferative and Caspase-3 Activation Activities 2019
143 Aryl Azide-Sulfonamide Hybrids Induce Cellular Apoptosis: Synthesis and Preliminary Screening of Their Cytotoxicity in Human HCT116 and A549 Cancer Cell Lines 2019
144 Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies 2018
145 Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds 2018
146 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
147 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
148 Novel Pyrrol-2(3H)-ones and Pyridazin-3(2H)-ones Carrying Quinoline Scaffold as Anti-Proliferative Tubulin Polymerization Inhibitors 2018
149 Novel N-Substituted 5-aminosalicylamides as Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase Enzymes: Synthesis, Biological Evaluation and Docking Study 2018
150 Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils 2018