Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
201 Facile Synthesis, Molecular Docking, and Biological Screening of 1,3-Disubstituted Urea Derivatives 2014
202 In Silico Studies of Quinoxaline-2-Carboxamide 1,4-di-N-Oxide Derivatives as Antimycobacterial Agents 2014
203 Surface plasmon resonance – more than a screening technology: insights in the binding mode of σ70:core RNAP inhibitors 2014
204 Synthesis and Characterization of bis-3,5-Disubstituted Thiadiazine-2-thione Derivatives as Anticancer Agents 2014
205 Design, Synthesis and Molecular Docking of Some New 1,2,4-Triazolobenzimidazol-3-yl Acetohydrazide Derivatives with Anti-Inflammatory-Analgesic Activities 2013
206 Synthesis and antimicrobial evaluation of some new thiazoline and
thiazolidinone derivatives incorporating [1, 2, 4] triazolo [1, 5-a]
benzimidazole. 		2013
207 Design, Synthesis and Molecular Docking of Some New 1,2,4-Triazolobenzimidazol-3-yl Acetohydrazide Derivatives with Anti-Inflammatory-Analgesic Activities 2013
208 Synthesis and antimicrobial evaluation of some new thiazoline and
thiazolidinone derivatives incorporating [1, 2, 4] triazolo [1, 5-a]
benzimidazole. 		2013
209 A Combined Experimental Green Flow-Injection Procedure and Computational Analysis to Determine Amino Acids 2013
210 Steroid derivatives as inhibitors of steroid sulfatase 2013