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Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
111 Optimizing the Photocontrol of bZIP Coiled Coils with Azobenzene Crosslinkers: Role of the Crosslinking Site 2015
112 Cu (I) Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition (CuAAC): Synthesis of 17α-[1-(Substituted Phenyl)-1,2,3-Triazol-4-yl]-19-Nortestosterone-17β-yl Acetates Targeting Progestational and Antipro-Liferative Activities 2015
113 Charge-Transfer Reaction of 1,4-Benzoquinone with Crizotinib: Spectrophotometric Study, Computational Molecular Modeling and Use in Development of Microwell Assay for Crizotinib 2014
114 High Throughput Microwell Spectrophotometric Assay for Olmesartan Medoxomil in Tablets Based on its Charge-Transfer Reaction with DDQ 2014
115 Synthesis and Characterization of bis-3,5-Disubstituted Thiadiazine-2-thione Derivatives as Anticancer Agents 2014
116 Synthesis of Novel Steroidal 17 a-Triazolyl Derivatives via Cu(I)-Catalyzed Azide-Alkyne Cycloaddition and their Evaluation as Potential Progestational Agents 2014
117 Peptide Arrays for Detecting Naphthenic Acids in Oil Sands Process Affected Water 2014
118 Structural Similarity between β(3) -Peptides Synthesized from β (3) -Homo-amino Acids or L-Aspartic Acid Monomers. 2014
119 Small-Molecule Inhibitors of 25-Hydroxyvitamin D-24-
Hydroxylase (CYP24A1): Synthesis and Biological Evaluation.
2014
120 In Silico Docking, Molecular Dynamics and Binding Energy Insights into the Bolinaquinone-Clathrin Terminal Domain Binding Site 2014