Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
171 Design and Synthesis of Some Substituted Thiazolo[3,2-a]Pyrimidine Derivatives of Potential Biological Activities 2016
172 Design and Synthesis of Ligands and Antagonists of Siglecs as Immune Response Modifiers 2016
173 Synthesis and Pharmacokinetic studies of Effective and Safe New Antimicrobial Derivatives of Substitited Hydroquinoxaline-2,3-diones 2016
174 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
175 Synthesis and Preliminary Biological Screening of 6-Aminopyrazolo[3,4-b]pyridine Derivatives 2016
176 Synthesis of B- and C-Ring-Modified Lithocholic Acid Analogues as Potential Sialyltransferase Inhibitors 2016
177 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
178 Synthesis of Some Benzimidazole Derivatives Endowed with 1,2,3-Triazole as Potential Inhibitors of Hepatitis C Virus 2016
179 Nature-Inspired Design of Tetraindoles: Optimization of the Core Structure and Evaluation of Structure–Activity Relationship 2016
180 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016