Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
191 Synthesis, anti-inflammatory and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetone thiosemicarbazone cyclized derivatives as PLA-2 inhibitors 2015
192 Synthesis, anti-inflammatory and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetone thiosemicarbazone cyclized derivatives as PLA-2 inhibitors 2015
193 Synthesis and biological evaluation of cystobactamid 507: A bacterial topoisomerase inhibitor from Cystobacter sp. 2015
194 Synthesis and investigation of antihypertensive activity using anaesthetized normotensive nonhuman primates of some 2-aryl-4-(substituted) pyrimido[1,2-a] benzimidazoles 2015
195 A-ring Substituted 17 β-Arylsulfonamides of 17β-Aminoestra-1,3,5(10)-trien-3-ol as Highly Potent Reversible Inhibitors of Steroid Sulfatase 2015
196 Discovery of New HER2/EGFR Dual Kinase Inhibitors Based on the Anilinoquinazoline Scaffold as Potential Anti-Cancer Agents 2014
197 Design and Synthesis of New (SecinH3) Derivatives as Potential Cytohesin Inhibitors 2014
198 Design and synthesis of new pyrido[2,3-d]pyrimidine-1,4-dione derivatives as anti-inflammatory agents 2014
199 Facile Synthesis, Molecular Docking, and Biological Screening of 1,3-Disubstituted Urea Derivatives 2014
200 In Silico Studies of Quinoxaline-2-Carboxamide 1,4-di-N-Oxide Derivatives as Antimycobacterial Agents 2014