Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
231 Synthesis of Some Benzimidazo-1,2,4-Triazole Derivatives with Antimicrobial and Anti- inflammatory Activities 2011
232 CD22-Antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold 2011
233 Design and Synthesis of some New Theophylline Derivatives with Bronchodilator and Antibacterial Activities 2011
234 Design, Synthesis, and Antidiabetic Activity of Some New 4-amino (or 6-oxo)-2-Methy / Benzylthio (or substituted amino) pyrimidine derivatives 2011
235 Design and Synthesis of some New Theophylline Derivatives with Bronchodilator and Antibacterial Activities 2011
236 Design, Synthesis, and Antimicrobial Activity of Newl 1,4-disubstituted octahydro- quinoxaline-2,3-diones 2011
237 Synthesis of New 4,5-3(2H)pyridazinone Derivatives and their
Cardiotonic, Hypotensive, and Platelet Aggregation Inhibition
Activities 		2010
238 Synthesis of New 4,5-3(2H)pyridazinone Derivatives and their
Cardiotonic, Hypotensive, and Platelet Aggregation Inhibition
Activities 		2010
239 Albumin-Based Nanoparticles as Magnetic Resonance Contrast Agents: I. Concept, First Syntheses and Characterisation 2010
240 Albumin-based Nanoparticles as Magnetic Resonance Contrast Agents: II. Physico-chemical Characterisation of Purified and Standardised Nanoparticles 2010