Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
141 Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types 2019
142 Self-Assembled Tannic Acid Complexes for pH-Responsive Delivery of Antibiotics: Role of Drug-Carrier Interactions 2019
143 Stereoselective trimethylsilylation of α- and β-galactopyranoses 2019
144 Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils 2018
145 Design, Synthesis, Mechanistic and Histopathological Studies of Small-Molecules of Novel Indole-2-Carboxamides and Pyrazino[1,2-a]indol-1(2H)-ones as Potential Anticancer Agents Effecting the Reactive Oxygen Species Production 2018
146 Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils 2018
147 Proximity Labeling of Cis-Ligands of CD22/Siglec-2 Reveals Stepwise 2,6 Sialic Acid-Dependent and -Independent Interactions 2018
148 Design, Synthesis, Mechanistic and Histopathological Studies of Small-Molecules of Novel Indole-2-Carboxamides and Pyrazino[1,2-a]indol-1(2H)-ones as Potential Anticancer Agents Effecting the Reactive Oxygen Species Production 2018
149 Synthesis, Biological Evaluation and Docking Study of 1,3,4-Thiadiazole-Thiazolidinone Hybrids as Anti-Inflammatory Agents with Dual Inhibition of COX-2 and 15-LOX 2018
150 Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) Butane as a Scaffold of Anti-Proliferative Activity, Blended by a Multicomponent Process 2018