Objective: The objective of the present study was to compare the effect of mixing simvastatin with Nanobone graft on the healing process of extraction sockets regarding to the histological parameter.

Materials and Methods: In a prospective randomized clinical study, ten patients (study group, Group II) treated by simvastatin mixed with Nanobone after tooth extraction. The other ten patients (Control group, Group I) received Nanobone only. Three months after tooth extraction and socket preservation, histological biopsies were taken at the time of implant placement. The biopsies were evaluated in the terms of the histological parameter for the identification of vascularization and bone metabolism factors.

Results: The use of simvastatin combination results in slightly higher values of mineralized area of newly formed bone andnumerous well differentiated capillary vascularization.

Conclusion: Simvastatin and Nanobone combination showed improvement in socket preservation.