Background: Post-operative nursing protocol for patients with partially edentulous has a vital role in improving oral health status and increase dental implant success rate. The current study aimed to evaluate the effect of postoperative nursing protocol on oral health status and dental implant success among patients with partially edentulous. Research design: Posttest only nonequivalent groups design was used to utilize this study. Setting: The study conducted at the outpatient clinics in the Oral& Maxillofacial Surgery Department at Assuit University Dental Hospital. Sample: 40 Dental implant in partially edentulous patients. Tools: Tool (I): Oral& maxillofacial interview assessment questionnaire. Tool (2): Observation check list for dental implant care. Tool (3): Probing depth scale. Tool (4): Pain assessment scale (VAS). Results: Two thirds of the patients in the study group were female, according to this study with age range from 30 > 40yrs old and showed significant decrease in average probing depths& demonstrated significant reduction in pain intensity when compared to the control group. In addition, all implant stability in both groups were stable. Conclusion: Implementation of post-operative nursing protocol among patients with partial edentulous showed an improvement on their oral health status and increase dental implant success rate. Recommendation: Continuous implementation of post-operative nursing protocol to upgrade dental implant success rate among patients with partial edentulous. As well encourage nurses to upgrade their information regarding dental care and to get dental nursing diploma or other academic dental nursing degree.