Seismic pounding between adjacent buildings is a critical hazard, particularly when combined with in-plane eccentricity from irregular loading. Although earthquake-induced collisions are well documented, the combined influence of eccentricity on pounding responses remains largely unexplored. This study investigates adjacent buildings with eccentricities of 5%, 10%, and 20% for three height configurations: 4–8, 4–12, and 8–12 stories. Nonlinear time-history-analysis evaluates drift, acceleration, and rotation demands under pounding and no-pounding conditions. Increasing eccentricity amplifies torsional demands, with pounding causing rotational increases of 165%, 124%, and 147% for the three configurations. Peak rotations reached 0.005–0.018, 0.0039–0.014, and 0.007–0.016 rad as eccentricity increased from 5% to 20%. Pounding also amplified member forces, particularly perimeter-column shear at high eccentricities, whereas its relative contribution to torsional moments decreased as inherent eccentricity became dominant. Conventional separation provisions may underestimate pounding risk, highlighting the need to incorporate load-induced eccentricity in seismic gap design.