Fujairah honey, collected from the mountainous regions of the United Arab Emirates, represents promising natural sources of functional food and pharmacological potential. This study aimed to characterise the functional food properties of crude Fujairah honey and to employ fractionation approaches to identify constituents with anticancer potential. Twenty Fujairah honey samples (Samar and Sidr) obtained from distinct locations of Fujairah Emirate were evaluated and compared with Manuka honey. The relationship between cytotoxicity, physicochemical properties, and underlying molecular mechanisms including antioxidant capacity, anti-inflammatory, and antimetastatic effects was investigated. Among the samples, Sample 6 (Samar honey derived from Acacia species) demonstrated selective cytotoxic activity following fractionation. While the crude honey promoted cell proliferation, its dichloromethane (DCM) fraction induced a 20% reduction in Michigan Cancer Foundation-7 (MCF-7) cell viability. Sample 6 DCM exhibits strong antioxidant activity (92.47% 2,2-diphenyl-1-picrylhydrazyl-hydrate radical scavenging), antimetastatic effects, and significant anti-inflammatory effects through Interleukin-6 (IL-6) downregulation (p < .0001) without excessive immune stimulation. Metabolomics profiling revealed elevated levels of fatty acids and monoacylglycerides, and succinic acid (with 28% enhanced cytotoxicity), supporting the unique activity of Samar (particularly Sample 6) honey. Driven by Fujairah’s arid climate and unique flora, Fujairah honey emerges as a promising source of novel pharmaceutical and
nutritional applications, offering distinctive anticancer and immunomodulatory properties.

Skin and prostate cancers pose therapeutic challenges due to drug resistance. Attalea butyracea, a Neotropical palm with pro￾found ethnobotanical significance, remains largely unexplored for anticancer constituents. This study aimed to isolate bioactive metabolites from A. butyracea, assess their selective cytotoxicity against A-431 and PC-3 cancer cells relative to normal cells, and explore their potential molecular targets. High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI/MS) and one- and two-dimensional nuclear magnetic resonance (1D/2D NMR) spectroscopy provided structural confirmation. Cytotoxic activity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Computational inverse docking and molecular dynamics simulations identified probable kinase targets, which were subsequently confirmed through enzyme inhibition assays. Phytochemical investigation yielded 17 compounds, including two previously undescribed glycosides, one megastigmane, and one flavonolignan. This marks the first report of flavonolignans within Attalea. Among isolated metabolites, calquiquelignan D showed notable activity, with CC50 values of 14.9 μM (A431) and 22.5 μM (PC3), comparable to those of cisplatin. Within the ATP pockets of oncogenic kinases, this compound demonstrated stable binding patterns as determined by computational analysis. Enzyme inhibition assays confirmed dual inhibition of ERK2 and PI3Kα at nanomolar concentrations.These findings suggest potential dual-pathway modulation of survival signaling. As chemotaxonomic markers with structurally distinct scaffolds, these metabolites merit further kinase-targeted drug development.