Analgesic Effect of Morphine Added to Bupivacaine in Serratus Anterior Plane Block Following Modified Radical Mastectomy. Only a Local Effect? Randomized Clinical Trial

Faculty of Pharmacy

Assiut University

Analgesic Effect of Morphine Added to Bupivacaine in Serratus Anterior Plane Block Following Modified Radical Mastectomy. Only a Local Effect? Randomized Clinical Trial

Research Authors
Fatma A El Sherif, Ahmad M Abd El-Rahman, Ahmed H Othman, Samia A Shouman, Mervat M Omran, Nivin A Hassan, Sahar B Hassan, Ebrahim Aboeleuon
Research Date
Research Department
Department of Clinical Pharmacy
Research Journal
Journal of pain research
Research Publisher
Dove Press
Research Vol
13
Research Year
2020
Research Member
Sahar Badr Hassan Khalil
Research_Pages
661
Research Abstract

Background

Serratus anterior plane (SAP) block, a novel regional anesthetic procedure, involves the anterolateral chest wall. Opioid receptors have been found on peripheral nerve terminals, so morphine may have a local action.

Objective

This work aimed at exploring the analgesic efficacy of morphine added to bupivacaine in SAPB in patients for whom modified radical mastectomy was conducted and whether it is a mere local effect.

Methods

Forty female patients were planned to have modified radical mastectomy participated in the study. Patients were randomly divided into two groups; Control group (C): received ultrasound-guided serratus anterior plane block with 20 mL of bupivacaine hydrochloride 0.25%; Morphine group (M): received the same in addition to 10 mg morphine sulfate. Intra-and post-operative blood samples were taken for the assessment of morphine serum levels. All patients were assessed for …