LPS and STZ induced-diabetes are known to cause oxidative stress in vivo. Female rats were given STZ (50mg/kg, i.p. once) prior to exposure to either LPS (5 mg/kg body weight) or 3 daily doses of STZ). One week after LPS or STZ treatment, oxidative stress was determined by measuring changes in antioxidant enzyme activities (GPx, GR, SOD, CAT, GST& GGT)and GSH content. In addition, to measureing LPO and NO in liver, kidney, intestine and spleen tissues. The obtained results suggests that STZ, like LPS may confer a protective effect against subsequent oxidative stress.