Animal kingdom posseses numerous species that produce toxins. snakes and scorpion posseses the most diverse animal toxins in the animal kingdom. BPPs are pyroglutamyl proline rich in oligopolypeptides. BPP isolated from Bothrops jararaca venom were described in the middle of 1960 as a first natural inhibitors of the ACE. Among the 18 natural peptides whose sizes vary between 5 and 14 amino acids, the most potent is BPP 5a, and BPP 9a.Recently these peptides have been used as probes selective tools in the study of physiological possesses and in the development of therapeuic agents.Therefore, BPPs hold great promise in the future understanding and treatment of cardiovascular diseases.