Egypt in 2015 announced the alteration of the fuels used in cement plants without the least regard to minimizing the environmental burden (EB) excesses. This study conducts a life-cycle assessment (LCA) of Egyptian cement-manufacturing unit, which is considered as the first one on LCA cement analysis to be conducted in Egypt. This study investigates the LCA of the cement industry in Egypt compared to the Swiss industry, using two methodologies. The first one has been done on-site, surveying the most common types of cement used in the construction industry in Egypt. Meanwhile, SimaPro software has been used to assess the environmental impacts, and three different cement plants were selected for this study: an Egyptian cement plant (ECP) which uses electricity, natural gas, and diesel as energy sources; a Swiss cement plant (SCP) which depends mainly on electricity, natural gas, and coal; and an Egyptian hypothetical plant (EHP) in which electricity and coal are assumed to be the main energy feeds, and comparisons of different strategies including midpoint and endpoint methods are outlined. Regarding the midpoint method, ETP recorded higher respiratory inorganics, aquatic acidification, global warming, and nonrenewable energy impacts than ECP, because of using coal, while for SCP, global warming and respiratory inorganics achieved the highest adverse impacts compared to ECP and EHP—due to the different manufacturing technology used. With regard to the endpoint method, the peak possibility of human health deterioration has been recorded due to the use of coal as fuel. This possibility was reduced by 46 % in the case of SCP as a result of the technology applied, which interestingly represents a reasonable reduction in terms of technological application.