Housing in Egypt consumes high energy for cooling. Bioclimatic building design is one of the strategies of sustainable devel-opment. This study aims to investigate the thermal performance and indoor air quality of solar chimney with passive cooling wind tower (SCPCW) on occupant’s comfort. Thermal performance of a full-scale SCPCW was experimentally investigated. The passive cooling design is integrated on the ceiling of 30m2 test house. Monitoring of indoor environment was carried out over a period of 2months in the summer season (August, September and early October) with a 2-min interval in order to calculate thermal comfort sensation, Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied. The results show that outlet air temperature from the wind tower is 27.3°C. Also, the calculated PMV is within the recommended range (− 0.5 < PMV < + 0.5). This indicates that occupants remain satisfied with indoor thermal environment after using the passive cooling system and the temperature difference between outdoor and indoor is approximately 8°C. The system achieves the acceptable air flow rate with average 450ppm for CO2 concentration during daytime. The results of this research provide information of the system applicability in the climate of Assiut during daytime in order to develop and install on top of real residential buildings in New Assiut, Egypt.